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New England Journal of Medicine· 2013Q1

A Phase 2 Trial of Ponatinib in Philadelphia Chromosome–Positive Leukemias

Jörge E. Cortes, D. W. Kim, Javier Pinilla‐Ibarz, Philipp le Coutre et al.

Short summary

Ponatinib achieved significant antileukemic activity in heavily pretreated patients with chronic myeloid leukemia (CML) or Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph-positive ALL), including those with the T315I mutation resistant to other TKIs.

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Field: Hematology

HematologyMedicine