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The Journal of Experimental Medicine· 2012Q1

Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo

Marie-Luise von Brühl, Konstantin Stark, Alexander Steinhart, Sue Chandraratne et al.

Short summary

Researchers developed a novel mouse model of deep vein thrombosis (DVT) and found that monocytes and neutrophils initiate the condition by activating coagulation, while neutrophils and platelets propagate it through NETs and leukocyte recruitment, respectively.

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Field: Internal Medicine

Internal MedicineMedicine