International Journal of Laboratory Hematology· 2015Q2
Comparison between different <scp>D</scp>‐<scp>D</scp>imer cutoff values to assess the individual risk of recurrent venous thromboembolism: analysis of results obtained in the <scp>DULCIS</scp> study
- 903citations
- Q2SCImago
- 2015year
Short summary
The DULCIS study found that age- and gender-specific D-dimer cutoff levels, lower for those <70 years and males, identified half the recurrent VTE events in younger subjects compared to traditional or other age-adjusted criteria.
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Key points
- The DULCIS study used age (<70 years) and gender (males) specific D-dimer cutoff levels.
- These DULCIS cutoffs identified half the recurrent VTE events in younger subjects compared to traditional or other age-adjusted criteria.
- In elderly patients, DULCIS cutoffs were similar to age-adjusted criteria.
- Traditional VTE exclusion criteria would have yielded many positive results in elderly subjects without reducing recurrent event rates.
AI-generated from the title and abstract; the full text is not read.
Abstract
INTRODUCTION: D-dimer assay, generally evaluated according to cutoff points calibrated for VTE exclusion, is used to estimate the individual risk of recurrence after a first idiopathic event of venous thromboembolism (VTE). METHODS: Commercial D-dimer assays, evaluated according to predetermined cutoff levels for each assay, specific for age (lower in subjects <70 years) and gender (lower in males), were used in the recent DULCIS study. The present analysis compared the results obtained in the DULCIS with those that might have been had using the following different cutoff criteria: traditional cutoff for VTE exclusion, higher levels in subjects aged ≥60 years, or age multiplied by 10. RESULTS: In young subjects, the DULCIS low cutoff levels resulted in half the recurrent events that would have occurred using the other criteria. In elderly patients, the DULCIS results were similar to those calculated for the two age-adjusted criteria. The adoption of traditional VTE exclusion criteria would have led to positive results in the large majority of elderly subjects, without a significant reduction in the rate of recurrent event. CONCLUSION: The results confirm the usefulness of the cutoff levels used in DULCIS.
The authors' abstract, as published at the source. International Journal of Laboratory Hematology, 2015 · DOI ↗
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Field: Internal Medicine
Internal MedicineMedicine