Blood· 2014Q1· Review
Direct oral anticoagulants compared with vitamin K antagonists for acute venous thromboembolism: evidence from phase 3 trials
- 843citations
- Q1SCImago
- 2014year
Short summary
Direct oral anticoagulants (DOACs) showed similar efficacy to vitamin K antagonists (VKAs) in preventing recurrent venous thromboembolism (VTE) (2.0% vs. 2.2%) but significantly reduced major bleeding risk (RR 0.61) across 6 phase 3 trials involving 27,023 patients.
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