mSystems· 2020Q1
Comparative Genomics and Metabolomics in the Genus <i>Nocardia</i>
- 73citations
- Q1SCImago
- 2020year
Short summary
Nocardia bacteria are a prolific source of natural products, comparable to well-known genera like Streptomyces, and their biosynthetic gene clusters can be distinguished and analyzed using high-stringency similarity networks for drug discovery.
AI-generated from the title and abstract; the full text is not read.
Key points
- Nocardia genus is a prolific source of natural products, comparable to Streptomyces.
- Large-scale analysis of biosynthetic gene clusters is feasible using similarity networks.
- High stringency in similarity networks allows distinction and prediction of natural product structural variations.
- This facilitates future genomics-driven drug discovery campaigns.
AI-generated from the title and abstract; the full text is not read.
Abstract
Our work emphasizes that Nocardia represent a prolific source for natural products rivaling better-characterized genera such as Streptomyces or Amycolatopsis . Furthermore, we showed that large-scale analysis of biosynthetic gene clusters using similarity networks with high stringency allows the distinction and prediction of natural product structural variations. This will facilitate future genomics-driven drug discovery campaigns.
The authors' abstract, as published at the source. mSystems, 2020 · DOI ↗
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Field: Microbiology
MicrobiologyMedicine