Journal of Global Antimicrobial Resistance· 2019Q2
Antimicrobial susceptibility profiles and species distribution of medically relevant Nocardia species: Results from a large tertiary laboratory in Australia
- 62citations
- Q2SCImago
- 2019year
Short summary
A study of 270 Nocardia isolates in Australia revealed Nocardia nova complex (29.6%) as the most common species, with 59.3% exhibiting resistance to imipenem and 9.3% to trimethoprim/sulfamethoxazole (SXT). Linezolid and amikacin showed high susceptibility across all tested isolates.
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Key points
- Nocardia nova complex (29.6%), N. cyriacigeorgica (22.6%), N. brasiliensis (19.3%), and N. farcinica (14.1%) were the most common Nocardia species identified.
- High rates of resistance were observed for imipenem (59.3%) and trimethoprim/sulfamethoxazole (SXT) (9.3%).
- Nocardia farcinica was the most frequent species showing resistance to SXT.
- All tested Nocardia isolates remained susceptible to linezolid, and only 0.7% showed resistance to amikacin.
AI-generated from the title and abstract; the full text is not read.
Abstract
OBJECTIVES: There are limited surveillance studies on the epidemiology and resistance rates ofNocardia spp. in Australia, particularly in the jurisdiction of New South Wales. This study aimed to investigate the species distribution and antimicrobial susceptibility of a large number of contemporary (2011-2016) clinical Nocardia spp. referred to a large tertiary hospital in Sydney, Australia. METHODS: A total of 270Nocardia spp. isolates identified to species level by dual-target gene sequencing were investigated. Antimicrobial susceptibility testing was performed using a Sensititre™ RAPMYCOI panel, with the minimum inhibitory concentration (MIC) range and geometric mean MIC obtained for each species and drug combination. Antimicrobial susceptibility profiles and species distribution were analysed. RESULTS: The respiratory system is the most affected site in nocardiosis. In this study, Nocardia nova complex was the most frequently isolated Nocardia spp. (n = 80; 29.6%), followed by Nocardia cyriacigeorgica (n = 61; 22.6%), Nocardia brasiliensis (n = 52; 19.3%) and Nocardia farcinica (n = 38; 14.1%). Of the tested isolates, 9.3% and 59.3% displayed resistance to trimethoprim/sulfamethoxazole (SXT) and imipenem, respectively. Nocardia farcinica accounted for the highest number of SXT-resistant isolates. High imipenem resistance in N. cyriacigeorgica is atypical to its drug pattern but has been reported elsewhere. All tested isolates remained susceptible to linezolid, with only 0.7% exhibiting resistance to amikacin. CONCLUSION: Linezolid and amikacin remain good empirical options for treatment of nocardiosis. Routine antimicrobial susceptibility testing ofNocardia is advisable with the detection of sulfonamide resistance and atypical antibiograms in this study.
The authors' abstract, as published at the source. Journal of Global Antimicrobial Resistance, 2019 · DOI ↗
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Field: Microbiology
MicrobiologyMedicine