Stem Cell Research & Therapy· 2026Q1· Review
Decoding the adipose-fibrotic axis: multi-organ mechanisms, crosstalk networks and emerging therapeutic targets
- 0citations
- Q1SCImago
- 2026year
Short summary
Adipose tissue actively drives fibrotic remodeling across multiple organs (skin, heart, liver, intestine) through mechanisms like adipokine signaling and adipocyte-to-myofibroblast transition, establishing a unifying adipose-fibrotic axis.
AI-generated from the title and abstract; the full text is not read.
Key points
- Adipose tissue acts as an endocrine and immunometabolic organ influencing fibrotic remodeling beyond its boundaries.
- Key mechanisms include adipokine signaling, adipocyte-to-myofibroblast transition, disordered lipid metabolism, and microbiome-mesenteric fat interactions.
- A stage-dependent model suggests early lipolysis is protective, while sustained lipolysis promotes fibrosis.
- Emerging therapeutic strategies involve adipose-derived stem cells (ADSCs), exosomes, metabolic interventions (browning/thermogenesis), and microbiome-directed approaches.
AI-generated from the title and abstract; the full text is not read.
Abstract
Adipose tissue is a dynamic endocrine and immunometabolic organ that shapes fibrotic remodeling within and beyond its anatomical boundaries. This review synthesizes evidence across skin, heart, liver and intestine to articulate a unifying adipose-fibrotic axis. We highlight depot- and stage-specific mechanisms, including adipokine signaling, adipocyte-to-myofibroblast transition, disordered lipid metabolism, and microbiome-mesenteric fat interactions, and distill convergent pathways. We further propose a stage-dependent model in which early lipolysis can be protective whereas sustained lipolysis promotes fibrosis, yielding testable therapeutic windows. Finally, we map a transitional landscape spanning cellular (ADSCs/exosomes), metabolic (browning/thermogenesis) and microbiome-directed strategies, and we outline outstanding questions for clinical translation.
The authors' abstract, as published at the source. Stem Cell Research & Therapy, 2026 · DOI ↗
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