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Brain· 2013Q1

Disease duration and the integrity of the nigrostriatal system in Parkinson’s disease

Jeffrey H. Kordower, C. Warren Olanow, Hemraj B. Dodiya, Yaping Chu et al.

Short summary

Parkinson's disease causes rapid loss of dopaminergic markers in the dorsal putamen, virtually complete by 4 years post-diagnosis, while melanized nigral neuron loss lags behind.

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Field: Neurology (Medicine)

NeurologyMedicine