BMJ· 2019Q1
Pre-eclampsia: pathophysiology and clinical implications
- 1,231citations
- Q1SCImago
- 2019year
Short summary
Pre-eclampsia, a common pregnancy disorder, arises from soluble factors released by a stressed placenta, with early onset linked to defective placentation and late onset to placental aging interacting with maternal genetic predispositions.
AI-generated from the title and abstract; the full text is not read.
Key points
- Pre-eclampsia stems from soluble factors released by a stressed placenta.
- Early onset pre-eclampsia is caused by defective placentation.
- Late onset pre-eclampsia may involve placental senescence and maternal genetic predisposition to cardiovascular/metabolic disease.
- Research is shifting towards translating placental-uterine interaction findings into clinical applications.
AI-generated from the title and abstract; the full text is not read.
Abstract
Pre-eclampsia is a common disorder that particularly affects first pregnancies. The clinical presentation is highly variable but hypertension and proteinuria are usually seen. These systemic signs arise from soluble factors released from the placenta as a result of a response to stress of syncytiotrophoblast. There are two sub-types: early and late onset pre-eclampsia, with others almost certainly yet to be identified. Early onset pre-eclampsia arises owing to defective placentation, whilst late onset pre-eclampsia may center around interactions between normal senescence of the placenta and a maternal genetic predisposition to cardiovascular and metabolic disease. The causes, placental and maternal, vary among individuals. Recent research has focused on placental-uterine interactions in early pregnancy. The aim now is to translate these findings into new ways to predict, prevent, and treat pre-eclampsia.
The authors' abstract, as published at the source. BMJ, 2019 · DOI ↗
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Field: Obstetrics and Gynecology
Obstetrics and GynecologyMedicine