BMJ· 2020Q1
Characteristics and outcomes of pregnant women admitted to hospital with confirmed SARS-CoV-2 infection in UK: national population based cohort study
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- Q1SCImago
- 2020year
Short summary
In a UK-wide study of 427 pregnant women hospitalized with SARS-CoV-2 (March-April 2020), 4.9 per 1000 maternities were affected, with 10% requiring respiratory support and 1% dying. Infant infection was uncommon (5%), with most cases occurring after birth.
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Key points
- Estimated incidence of hospital admission for SARS-CoV-2 in pregnancy was 4.9 per 1000 maternities.
- 56% of hospitalized pregnant women were from Black or other ethnic minority groups.
- 10% of admitted women required respiratory support, and 1% died.
- 5% of infants tested positive for SARS-CoV-2 RNA, with most infections occurring post-birth.
AI-generated from the title and abstract; the full text is not read.
Abstract
OBJECTIVES: To describe a national cohort of pregnant women admitted to hospital with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the UK, identify factors associated with infection, and describe outcomes, including transmission of infection, for mothers and infants. DESIGN: Prospective national population based cohort study using the UK Obstetric Surveillance System (UKOSS). SETTING: All 194 obstetric units in the UK. PARTICIPANTS: 427 pregnant women admitted to hospital with confirmed SARS-CoV-2 infection between 1 March 2020 and 14 April 2020. MAIN OUTCOME MEASURES: Incidence of maternal hospital admission and infant infection. Rates of maternal death, level 3 critical care unit admission, fetal loss, caesarean birth, preterm birth, stillbirth, early neonatal death, and neonatal unit admission. RESULTS: The estimated incidence of admission to hospital with confirmed SARS-CoV-2 infection in pregnancy was 4.9 (95% confidence interval 4.5 to 5.4) per 1000 maternities. 233 (56%) pregnant women admitted to hospital with SARS-CoV-2 infection in pregnancy were from black or other ethnic minority groups, 281 (69%) were overweight or obese, 175 (41%) were aged 35 or over, and 145 (34%) had pre-existing comorbidities. 266 (62%) women gave birth or had a pregnancy loss; 196 (73%) gave birth at term. Forty one (10%) women admitted to hospital needed respiratory support, and five (1%) women died. Twelve (5%) of 265 infants tested positive for SARS-CoV-2 RNA, six of them within the first 12 hours after birth. CONCLUSIONS: Most pregnant women admitted to hospital with SARS-CoV-2 infection were in the late second or third trimester, supporting guidance for continued social distancing measures in later pregnancy. Most had good outcomes, and transmission of SARS-CoV-2 to infants was uncommon. The high proportion of women from black or minority ethnic groups admitted with infection needs urgent investigation and explanation. STUDY REGISTRATION: ISRCTN 40092247.
The authors' abstract, as published at the source. BMJ, 2020 · DOI ↗
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Field: Obstetrics and Gynecology
Obstetrics and GynecologyMedicine