Journal of Chemistry· 2020Q2
Muscle Injury in Bodybuilding Based on Mesoporous Multifunctional Nanomaterials for Sports Rehabilitation Training
- 4citations
- Q2SCImago
- 2020year
Short summary
Mesoporous multifunctional nanomaterials loaded with AS1411 and Dimer-PPTcDA demonstrated targeted drug release for muscle injury rehabilitation in mice, showing low cytotoxicity (100% cell survival at 90 μg/mL) and effective cellular targeting.
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Key points
- Mesoporous multifunctional nanomaterials were designed for targeted drug delivery to muscle injury sites.
- AS1411 and Dimer-PPTcDA were used to control drug release from the nanomaterial pores.
- FAM-labeled AS1411 allowed real-time monitoring of drug release and targeting.
- Nanomaterials showed low cytotoxicity, with 100% cell survival at 90 μg/mL.
- Smaller particle size enhanced cellular invasion and targeting efficacy.
AI-generated from the title and abstract; the full text is not read.
Abstract
As an important means of treating diseases, chemical-based drugs have always guaranteed people’s health and longevity. However, due to the nature of some drugs, their use in the medical field is limited. This study mainly discusses the treatment of muscle damage based on sports rehabilitation training mesoporous multifunctional nanomaterials in bodybuilding. The biological characteristics of the targeted control of mesoporous multifunctional nanomaterials for target drugs were studied by analyzing the regeneration of skeletal muscles of mice after gastrocnemius strain under computer control. The electrostatic interactions modified by the consensus binding between AS1411 and Dimer-PPTcDA on the surface of mesoporous silicon are used to block the pores, and the release of objective molecules depends on the concentration of the drug in the tendon cells and the time of action. In this system, AS1411 has both the characteristics of the target substance and the active site of the targeted stimulus response in the cell. After FAM is labeled AS1411, the fluorescence of FAM can be used to monitor the release of the drug in real time, so as to directly release the drug to the lesion, maintain local effectiveness, and greatly improve the biological activity of the drug. In addition, in the safety analysis of mesoporous multifunctional nanomaterials on cells, if the concentration of nanoparticles is 90 μg/mL, the cell survival rate is almost 100%. The results show that the mesoporous multifunctional nanomaterials have low cytotoxicity and cell activity is not affected. The smaller the particle size of mesoporous silicon, the easier it is to invade the focus cells. In addition, confocal microscopy imaging has also effectively demonstrated the targeting effect of mesoporous multifunctional nanomaterials on cells.
The authors' abstract, as published at the source. Journal of Chemistry, 2020 · DOI ↗
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