Journal of Agricultural and Food Chemistry· 2026Q1
Design, Synthesis, and Antifungal Evaluation of Novel Perillaldehyde Oxadiazole Derivatives Bearing Hydrazide/Amide Moiety as Potential Succinate Dehydrogenase Inhibitors
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- Q1SCImago
- 2026year
Short summary
A novel perillyl-1,3,4-oxadiazole-hydrazide derivative (6d) showed potent antifungal activity against Monilinia fructicola (EC50: 0.10 mg/L), outperforming commercial fungicides bixafen and carbendazim, and demonstrated safety for non-target organisms.
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Key points
- Novel perillaldehyde oxadiazole derivative 6d shows potent antifungal activity against Monilinia fructicola (EC50: 0.10 mg/L).
- Derivative 6d outperformed commercial fungicides bixafen and carbendazim in antifungal efficacy.
- 6d demonstrated a favorable safety profile for non-target plants and animals.
- Mechanism studies indicate 6d inhibits succinate dehydrogenase (SDH) and disrupts mitochondrial function.
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Abstract
Abstract To discover novel fungicides, four series of oxadiazole-containing perillaldehyde derivatives bearing hydrazide/amide moieties were designed, synthesized and evaluated for antifungal activity against seven phytopathogens. Among them, a perillyl-1,3,4-oxadiazole-hydrazide derivative 6d exhibited the strongest activity against Monilinia fructicola (EC50: 0.10 mg/L), outperforming bixafen and carbendazim, and it displayed a favorable safety profile toward nontarget plants and animals. In vivo assays showed that 6d provided outstanding protective and curative effects on M. fructicola-infected peaches. Mechanism studies revealed that 6d induced morphological and ultrastructural damage, disrupted cell membrane integrity, triggered reactive oxygen species accumulation and loss of mitochondrial membrane potential, as well as inhibited succinate dehydrogenase (SDH) activity. Molecular docking further elucidated its binding mode with SDH. Transcriptomic analysis confirmed that 6d significantly altered gene expression related to oxidoreductase activity, oxidation–reduction processes and transmembrane transporter activity. These results demonstrate that 6d is a promising SDH-targeting fungicide candidate for controlling peach brown rot.
The authors' abstract, as published at the source. Journal of Agricultural and Food Chemistry, 2026 · DOI ↗
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