JCI Insight· 2017Q1· Review
Diabetic retinopathy: current understanding, mechanisms, and treatment strategies
- 1,051citations
- Q1SCImago
- 2017year
Short summary
Diabetic retinopathy (DR) is a leading cause of vision loss, and while treatments for its severe forms have improved, new therapies are needed to address the complex interplay of vascular, glial, and neuronal damage in the diabetic retina.
AI-generated from the title and abstract; the full text is not read.
Key points
- Diabetes disrupts the interdependent vascular, neuronal, glial, and immune cells within the retinal neurovascular unit.
- New therapeutic strategies are emerging by targeting these complex cellular interactions.
- Advances aim to prevent or reverse retinal neuronal dysfunction, vascular leakage, ischemia, and pathologic angiogenesis.
- Future treatments may allow for earlier intervention and personalized approaches for DR management.
AI-generated from the title and abstract; the full text is not read.
Abstract
Diabetic retinopathy (DR) causes significant visual loss on a global scale. Treatments for the vision-threatening complications of diabetic macular edema (DME) and proliferative diabetic retinopathy (PDR) have greatly improved over the past decade. However, additional therapeutic options are needed that take into account pathology associated with vascular, glial, and neuronal components of the diabetic retina. Recent work indicates that diabetes markedly impacts the retinal neurovascular unit and its interdependent vascular, neuronal, glial, and immune cells. This knowledge is leading to identification of new targets and therapeutic strategies for preventing or reversing retinal neuronal dysfunction, vascular leakage, ischemia, and pathologic angiogenesis. These advances, together with approaches embracing the potential of preventative or regenerative medicine, could provide the means to better manage DR, including treatment at earlier stages and more precise tailoring of treatments based on individual patient variations.
The authors' abstract, as published at the source. JCI Insight, 2017 · DOI ↗
Continue with a free account
Ask the paper: 3 free questions a day about this paper; save it, get its citation, new summaries every day for your field. Takeaways are Premium.
Continue free on the webSign in with Google or Apple; no card needed. You come back to this paper.
On your phone:
Field: Ophthalmology
OphthalmologyMedicine