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Journal of Occupational and Environmental Medicine· 2026Q2

Central Adiposity and Cardiometabolic Risk in Occupational Personnel: Nonlinear Associations with Lipid Risk and Aerobic Capacity

Yuhang Liu, Michael J. Conner, Jay J Dawes, Jacob Mota et al.

Short summary

Central adiposity, measured by android-to-gynoid fat ratio (A/G), shows nonlinear associations with key cardiometabolic risk markers (TG/HDL, AOPP) and VO₂peak in first responders, suggesting it better captures risk heterogeneity than BMI or aerobic capacity alone.

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Key points

  • Central adiposity (A/G ratio) demonstrated nonlinear associations with TG/HDL (F=13.7, p<0.01) and AOPP (F=5.25, p<0.01) in 170 first responders.
  • VO₂peak, TG/HDL, and estimated pulse wave velocity differed significantly across BMI-body fat phenotypes.
  • A modest nonlinear association was observed between A/G and VO₂peak, but indirect pathways were not supported.
  • Central adiposity appears to better reflect cardiometabolic risk heterogeneity than aerobic capacity in first responders.

AI-generated from the title and abstract; the full text is not read.

Abstract

Objective: To examine whether DXA-derived android-to-gynoid fat ratio (A/G) relates to cardiometabolic risk and aerobic capacity in first responders beyond BMI-based phenotypes. Methods: In this cross-sectional study, 170 first responders were categorized into four BMI–body fat phenotypes. Group differences in VO₂peak, A/G, and cardiometabolic markers were examined using ANCOVA. A/G was modeled continuously using linear regression, generalized additive models, and exploratory structural equation modeling. Results: VO₂peak, TG/HDL, and estimated pulse wave velocity differed across phenotypes. A/G showed nonlinear associations with TG/HDL (edf = 3.22, F = 13.7, p < 0.01) and AOPP (edf = 2.89, F = 5.25, p < 0.01). A/G showed a modest nonlinear association with VO₂peak, but indirect pathways were unsupported. Conclusions: Central adiposity may better reflect cardiometabolic heterogeneity than aerobic capacity in first responders.

The authors' abstract, as published at the source. Journal of Occupational and Environmental Medicine, 2026 · DOI ↗

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Field: Endocrinology, Diabetes and Metabolism

Endocrinology, Diabetes and MetabolismMedicine