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The Journal of Clinical Endocrinology & Metabolism· 2019Q1· Guideline

Pharmacological Management of Osteoporosis in Postmenopausal Women: An Endocrine Society Clinical Practice Guideline

Richard Eastell, Clifford J. Rosen, Dennis M. Black, Angela M. Cheung et al.

Short summary

New clinical practice guidelines recommend assessing fracture risk using country-specific tools and incorporating patient preferences for managing postmenopausal osteoporosis.

AI-generated from the title and abstract; the full text is not read.

Key points

  • Assess postmenopausal women's fracture risk using country-specific tools to guide treatment.
  • Incorporate patient preferences into osteoporosis treatment planning.
  • Combine nutritional, lifestyle, and fall prevention interventions with all pharmacologic regimens.
  • Multiple pharmacological therapies are effective in reducing fracture rates with acceptable risk-benefit profiles.

AI-generated from the title and abstract; the full text is not read.

Abstract

OBJECTIVE: The objective is to formulate clinical practice guidelines for the pharmacological management of osteoporosis in postmenopausal women. CONCLUSIONS: Evidence from clinical trials and insights from clinical experience with pharmacologic therapies for osteoporosis were critically evaluated in formulating this guideline for the management of postmenopausal osteoporosis. Patient preferences, data on adherence and persistence, and risks and benefits from the patient and provider perspectives were also considered in writing committee deliberations. A consensus by the Writing Committee members was achieved for four management principles: (i) The risk of future fractures in postmenopausal women should be determined using country-specific assessment tools to guide decision-making. (ii) Patient preferences should be incorporated into treatment planning. (iii) Nutritional and lifestyle interventions and fall prevention should accompany all pharmacologic regimens to reduce fracture risk. (iv) Multiple pharmacologic therapies are capable of reducing fracture rates in postmenopausal women at risk with acceptable risk-benefit and safety profiles.

The authors' abstract, as published at the source. The Journal of Clinical Endocrinology & Metabolism, 2019 · DOI ↗

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Field: Orthopedics and Sports Medicine

Orthopedics and Sports MedicineMedicine