European Journal of Neurology· 2018Q1· Review
Multiple sclerosis – a review
- 2,126citations
- Q1SCImago
- 2018year
Short summary
Multiple sclerosis (MS) is a growing global health concern, with increasing incidence and socioeconomic impact, yet its underlying causes and the reasons for its rise remain unclear.
AI-generated from the title and abstract; the full text is not read.
Key points
- MS incidence is increasing globally, posing a significant socioeconomic challenge.
- Potential contributing factors include low vitamin D, smoking, childhood obesity, and Epstein-Barr virus.
- Diagnostic methods are improving, allowing for earlier detection, even 'pre-symptomatic MS'.
- Treatment options for MS have expanded significantly in number, efficacy, and risk.
AI-generated from the title and abstract; the full text is not read.
Abstract
Multiple sclerosis (MS) is the commonest non-traumatic disabling disease to affect young adults. The incidence of MS is increasing worldwide, together with the socioeconomic impact of the disease. The underlying cause of MS and mechanisms behind this increase remain opaque, although complex gene-environment interactions almost certainly play a significant role. The epidemiology of MS indicates that low serum levels of vitamin D, smoking, childhood obesity and infection with the Epstein-Barr virus are likely to play a role in disease development. Changes in diagnostic methods and criteria mean that people with MS can be diagnosed increasingly early in their disease trajectory. Alongside this, treatments for MS have increased exponentially in number, efficacy and risk. There is now the possibility of a diagnosis of 'pre-symptomatic MS' being made; as a result potentially preventive strategies could be studied. In this comprehensive review, MS epidemiology, potential aetiological factors and pathology are discussed, before moving on to clinical aspects of MS diagnosis and management.
The authors' abstract, as published at the source. European Journal of Neurology, 2018 · DOI ↗
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Field: Pathology and Forensic Medicine
Pathology and Forensic MedicineMedicine