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Journal of Biological Regulators and Homeostatic Agents/Journal of Biological Regulators & Homeostatic Agents· 2020

Induction of pro-inflammatory cytokines (IL-1 and IL-6) and lung inflammation by COVID-19: anti-inflammatory strategies.

Pio Conti

Short summary

COVID-19 infection triggers pro-inflammatory cytokines IL-1β and IL-6, leading to lung inflammation, fever, and fibrosis via TLR and inflammasome activation. The novel cytokines IL-37 and IL-38 suppress these inflammatory pathways, presenting potential therapeutic strategies.

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Field: Pharmacology

PharmacologyMedicine