Biomedical Microdevices· 2026Q2· Review
Deformable discoidal polymeric nanoconstructs: Design principles, therapeutic applications, and translational perspectives
- 0citations
- Q2SCImago
- 2026year
Short summary
Deformable discoidal polymeric nanoconstructs (DPN) engineered with PLGA/PEG demonstrate improved drug delivery by promoting vascular margination and reducing immune clearance, showing enhanced efficacy in preclinical models for cancer and stroke.
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Key points
- DPN's discoidal geometry and deformability promote vascular margination and reduce phagocytic sequestration.
- PLGA/PEG composition enables tunable properties for drug delivery.
- DPN demonstrated enhanced therapeutic efficacy in preclinical models for triple-negative breast cancer, glioblastoma, and lung metastases.
- Surface-functionalized DPN improved clot targeting and thrombolysis in ischemic stroke models with reduced neurological toxicity.
AI-generated from the title and abstract; the full text is not read.
Abstract
Abstract Deformable Discoidal Polymeric Nanoconstructs (DPN) represent a biomimetic drug-delivery platform designed to overcome the limitations of conventional spherical nanoparticles. Their discoidal geometry, tunable deformability, and PLGA/PEG-based composition promote vascular margination, reduce phagocytic sequestration, prolong circulation, and enhance accumulation at pathological sites. This review highlights the design principles, fabrication strategies, therapeutic applications, and translational potential of DPN. In oncology, DPN have been engineered to improve the loading and sustained release of docetaxel through multi-passage fabrication, prodrug conjugation, and hierarchical micro-combinatorial hydrogel particles (µCGP). These discoidal particles enhanced therapeutic efficacy in preclinical models of triple-negative breast cancer, glioblastoma, and lung metastases. Beyond cancer, surface-functionalized DPN carrying tissue plasminogen activator improved clot targeting and thrombolysis while limiting neurological toxicity in ischemic stroke models. Overall, DPN integrate geometry, mechanics, and surface functionality to achieve vascular confinement, targeted delivery, and improved safety. Their modular design, biocompatible materials, and favorable preclinical performance support further development as versatile platforms for cancer therapy, metastatic disease, and thrombotic disorders.
The authors' abstract, as published at the source. Biomedical Microdevices, 2026 · DOI ↗
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Field: Biomaterials
BiomaterialsMaterials Science