Alzheimer s & Dementia· 2016Q1
Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria
- 1,919citations
- Q1SCImago
- 2016year
Short summary
A conceptual shift now defines Alzheimer's disease (AD) as a continuum, enabling identification at the preclinical, asymptomatic stage via biomarker research.
AI-generated from the title and abstract; the full text is not read.
Key points
- Alzheimer's disease is now conceptualized as a continuum.
- Biomarker research enables identification of preclinical, asymptomatic AD.
- Early intervention is a major research focus for potential therapeutic success.
- Clarification is needed on definitions, natural history, markers, and ethics of preclinical AD.
AI-generated from the title and abstract; the full text is not read.
Abstract
During the past decade, a conceptual shift occurred in the field of Alzheimer's disease (AD) considering the disease as a continuum. Thanks to evolving biomarker research and substantial discoveries, it is now possible to identify the disease even at the preclinical stage before the occurrence of the first clinical symptoms. This preclinical stage of AD has become a major research focus as the field postulates that early intervention may offer the best chance of therapeutic success. To date, very little evidence is established on this "silent" stage of the disease. A clarification is needed about the definitions and lexicon, the limits, the natural history, the markers of progression, and the ethical consequence of detecting the disease at this asymptomatic stage. This article is aimed at addressing all the different issues by providing for each of them an updated review of the literature and evidence, with practical recommendations.
The authors' abstract, as published at the source. Alzheimer s & Dementia, 2016 · DOI ↗
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Field: Psychiatry and Mental health
Psychiatry and Mental healthMedicine