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Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin· 2026Q1

Hybrid/collision ameloblastoma-ameloblastic fibroma: a case with molecular features supporting a tumor-in-tumor model

Melad Dababneh, Abdullah Ösme, Shuko Harada, Kelly Magliocca

Short summary

A rare mandibular odontogenic neoplasm exhibited distinct ameloblastic fibroma and ameloblastoma components, supporting a true hybrid/collision tumor model.

AI-generated from the title and abstract; the full text is not read.

Key points

  • A mandibular odontogenic neoplasm showed distinct ameloblastic fibroma and ameloblastoma components.
  • Molecular and morphologic features support a hybrid/collision tumor model.
  • This case provides evidence for a rare tumor phenomenon.
  • The WHO classification does not formally recognize this category.

AI-generated from the title and abstract; the full text is not read.

Abstract

Abstract Hybrid/collision odontogenic tumors are a rare and controversial phenomenon not formally recognized as a distinct category in the WHO Classification of Head and Neck Tumors and their diagnosis relies mainly on histomorphology. This report presents a unique mandibular odontogenic neoplasm with molecular and morphologic features in support of a true hybrid/collision process demonstrating distinct ameloblastic fibroma and ameloblastoma components.

The authors' abstract, as published at the source. Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin, 2026 · DOI ↗

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Field: Oral Surgery

Oral SurgeryDentistry