Journal of Agricultural and Food Chemistry· 2026Q1
Fermented Pomegranate Juice with Lactiplantibacillus plantarum CCFM1286 Attenuates Brain Aging in Association with PINK1/Parkin Activation
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- Q1SCImago
- 2026year
Short summary
Fermented pomegranate juice with Lactiplantibacillus plantarum CCFM1286 (CCFM1286FPJ) reversed brain aging in mice, improving behavior, reducing neuronal damage, and suppressing inflammation by activating PINK1/Parkin-mediated mitophagy and inhibiting senescence pathways.
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Key points
- Fermented pomegranate juice (CCFM1286FPJ) improved aging-related anxiety-like behaviors in mice.
- CCFM1286FPJ attenuated hippocampal neuronal damage and suppressed systemic inflammation.
- Mechanisms included inhibiting senescence pathways (p53/p21, p16) and apoptosis, while promoting PINK1/Parkin-mediated mitophagy.
- Metabolomic analysis identified pomegranate-specific metabolites (punicic acid, urolithins) and modulated tryptophan metabolism and the TCA cycle.
AI-generated from the title and abstract; the full text is not read.
Abstract
Abstract Urolithins, gut microbiota-derived metabolites of ellagic acid, demonstrate potential in mitigating aging-related physiological decline. This study investigated the neuroprotective effects and mechanisms of pomegranate juice fermented with Lactiplantibacillus plantarum CCFM1286 (CCFM1286FPJ) in mice with D-galactose-induced brain aging. CCFM1286FPJ intervention significantly improved aging-related anxiety-like behaviors, attenuated hippocampal neuronal damage, and lowered systemic inflammation. Mechanistically, CCFM1286FPJ suppressed glial activation, thereby inhibiting p53/p21 and p16 senescence-associated pathways and restoring BAX/Bcl-2 balance to suppress caspase-3-dependent apoptosis. Furthermore, CCFM1286FPJ promoted autophagy and induced PINK1/Parkin-mediated mitophagy. Serum metabolomics revealed the enrichment of pomegranate-specific metabolites, including punicic acid and urolithins, and identified modulation of tryptophan metabolism and the tricarboxylic acid cycle, implicating these pathways in the amelioration of neuroinflammation and the restoration of energy homeostasis. These results indicate that CCFM1286FPJ counteracts brain aging, potentially through multiple mechanisms involving fermentation-derived bioactives.
The authors' abstract, as published at the source. Journal of Agricultural and Food Chemistry, 2026 · DOI ↗
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Field: Nutrition and Dietetics
Nutrition and DieteticsNursing