Frontiers in Immunology· 2014Q1· Review

IgG Subclasses and Allotypes: From Structure to Effector Functions

Gestur Vidarsson, Gillian Dekkers, Theo Rispens

2,651citations
Q1SCImago
2014year

Short summary

The four IgG subclasses (IgG1, IgG2, IgG3, IgG4) exhibit distinct effector functions due to variations in their constant regions, impacting FcγR binding, complement activation, and FcRn interactions.

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Field: Radiology, Nuclear Medicine and Imaging

Radiology, Nuclear Medicine and ImagingMedicine