Scientific Reports· 2018Q1
Disrupted Resting State Network of Fibromyalgia in Theta frequency
- 44citations
- Q1SCImago
- 2018year
Short summary
Fibromyalgia patients exhibit decreased global brain connectivity and reduced connectivity within the default mode network and between temporal/visual cortices, particularly with longer pain duration.
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Key points
- Fibromyalgia patients show decreased global brain connectivity in the theta frequency band compared to healthy controls.
- Reduced connectivity is observed within the default mode network and between temporal and visual cortices in fibromyalgia patients.
- Longer pain duration in fibromyalgia is associated with decreased connectivity between the inferior temporal gyrus and visual cortex.
- Findings suggest aberrant resting state networks are linked to sensory processing dysfunction in chronic pain.
AI-generated from the title and abstract; the full text is not read.
Abstract
Fibromyalgia (FM), chronic widespread pain, exhibits spontaneous pain without external stimuli and is associated with altered brain activities during resting state. To understand the topological features of brain network in FM, we employed persistent homology which is a multiple scale network modeling framework not requiring thresholding. Spontaneous magnetoencephalography (MEG) activity was recorded in 19 healthy controls (HCs) and 18 FM patients. Barcode, single linkage dendrogram and single linkage matrix were generated based on the proposed modeling framework. In theta band, the slope of decrease in the number of connected components in barcodes showed steeper in HC, suggesting FM patients had decreased global connectivity. FM patients had reduced connectivity within default mode network, between middle/inferior temporal gyrus and visual cortex. The longer pain duration was correlated with reduced connectivity between inferior temporal gyrus and visual cortex. Our findings demonstrated that the aberrant resting state network could be associated with dysfunction of sensory processing in chronic pain. The spontaneous nature of FM pain may accrue to disruption of resting state network.
The authors' abstract, as published at the source. Scientific Reports, 2018 · DOI ↗
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Field: Cognitive Neuroscience
Cognitive NeuroscienceNeuroscience