Cell Reports· 2021Q1
Consolidation of human skill linked to waking hippocampo-neocortical replay
- 177citations
- Q1SCImago
- 2021year
Short summary
Waking neural replay, temporally compressed ~20-fold and selective for trained sequences, occurs during rest periods and predicts skill consolidation magnitude.
AI-generated from the title and abstract; the full text is not read.
Key points
- Waking neural replay was observed during rest periods following motor skill acquisition.
- Replay was temporally compressed by ~20-fold and selective for the trained sequence.
- The magnitude of replay predicted the degree of skill consolidation.
- Replay involved hippocampo-neocortical pathways, including sensorimotor cortex.
AI-generated from the title and abstract; the full text is not read.
Abstract
The introduction of rest intervals interspersed with practice strengthens wakeful consolidation of skill. The mechanisms by which the brain binds discrete action representations into consolidated, highly temporally resolved skill sequences during waking rest are not known. To address this question, we recorded magnetoencephalography (MEG) during acquisition and rapid consolidation of a sequential motor skill. We report the presence of prominent, fast waking neural replay during the same rest periods in which rapid consolidation occurs. The observed replay is temporally compressed by approximately 20-fold relative to the acquired skill, is selective for the trained sequence, and predicts the magnitude of skill consolidation. Replay representations extend beyond the hippocampus and entorhinal cortex to the contralateral sensorimotor cortex. These results document the presence of robust hippocampo-neocortical replay supporting rapid wakeful consolidation of skill.
The authors' abstract, as published at the source. Cell Reports, 2021 · DOI ↗
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Field: Cognitive Neuroscience
Cognitive NeuroscienceNeuroscience