Epigenetics & Chromatin· 2026Q1· Review
Epigenetic modulators of melanogenesis: the role of environment, lifestyle, and stress
- 0citations
- Q1SCImago
- 2026year
Short summary
Environmental and lifestyle factors like UV radiation and chemical exposure induce epigenetic changes (DNA methylation, histone modifications, etc.) that modulate melanogenesis-associated genes, impacting pigmentary disorders.
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Key points
- Melanogenesis, the process of melanin production, is influenced by genetics, environment, and epigenetics.
- Environmental and lifestyle factors (UV, chemicals, hormones) induce epigenetic changes like DNA methylation and histone modifications.
- These epigenetic changes modulate the expression of genes involved in melanogenesis.
- This modulation can lead to hyperpigmentation or hypopigmentation disorders.
AI-generated from the title and abstract; the full text is not read.
Abstract
Abstract Melanogenesis is the process through which a pigment called melanin is produced by melanocytes in melanosomes. Increased or decreased production of melanin through melanogenesis can lead to pigmentation diseases, namely, hyperpigmentation and hypopigmentation. Melanogenesis is controlled by various elements, including genetics, environmental factors, and epigenetic changes. Environmental and genetic factors such as UV radiation, chemical exposure, and hormonal changes can lead to epigenetic changes such as DNA methylation, histone modifications, noncoding RNA regulation, chromatin remodelling, and m6A RNA methylation, thereby modulating the expression of melanogenesis-associated genes. This review synthesizes current evidence on how environmental and lifestyle factors regulate melanogenesis through epigenetic mechanisms, highlights recent advances, and discusses their implications for understanding pigmentary disorders and developing targeted dermatological therapies.
The authors' abstract, as published at the source. Epigenetics & Chromatin, 2026 · DOI ↗
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Field: Cell Biology
Cell BiologyBiochemistry, Genetics and Molecular Biology