JAMA· 2016Q1
Prevalence of Immunosuppression Among US Adults, 2013
- 275citations
- Q1SCImago
- 2016year
Short summary
Immunosuppression peaked in US adults aged 50-59 years in 2013, increasing with age alongside chronic conditions but with an unexplained peak in this decade.
AI-generated from the title and abstract; the full text is not read.
Key points
- Immunosuppression prevalence in US adults peaked in the 50-59 age group in 2013.
- Prevalence increased with age, correlating with chronic conditions requiring immunosuppressive treatments.
- The specific reasons for the peak in the 50-59 age bracket remain unclear.
- Study limitations include reliance on self-reports, exclusion of children and institutionalized adults, and inability to determine specific causes of immunosuppression.
AI-generated from the title and abstract; the full text is not read.
Abstract
immunosuppression increased with age, in parallel with the epidemiology of prevalent conditions that require immunosuppressive treatments, but it is unclear why it peaked at ages 50 to 59 years.The study has limitations.Self-reports of immunosuppression are prone to misclassification, but the modest range of results in the sensitivity analyses provides reassurance regarding the potential influence of erroneous responses.With a limited number of survey questions, causes or subsets of immunosuppression could not be reliably determined.It is unknown whether data from 2013 reflect the current prevalence of immunosuppression.In addition, the study excluded children and institutionalized adults.This study addresses an underappreciated phenomenon and serves as a call for additional data from other sources to complement and fill the gaps in the study.Tracking immunosuppression over time is particularly important given the hundreds of clinical trials now under way to assess the use of immunosuppressive treatments for prevention or mitigation of common chronic diseases in highly prevalent risk groups.
The authors' abstract, as published at the source. JAMA, 2016 · DOI ↗
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Field: Transplantation
TransplantationMedicine