Science· 2016Q1
Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis
- 399citations
- Q1SCImago
- 2016year
Short summary
Hair follicle stem cell (HFSC) aging, triggered by DNA damage and subsequent proteolysis of COL17A1, leads to HFSC elimination from the skin and hair follicle miniaturization, causing hair loss in mice and humans.
AI-generated from the title and abstract; the full text is not read.
Key points
- Hair follicle stem cell (HFSC) aging is the primary driver of hair thinning and loss.
- DNA damage in HFSCs causes proteolysis of COL17A1, a critical molecule for HFSC maintenance.
- Aged HFSCs lose stemness, commit to epidermal differentiation, and are eliminated from the skin.
- COL17A1 deficiency recapitulates this aging process, while maintaining COL17A1 prevents it.
AI-generated from the title and abstract; the full text is not read.
Abstract
Hair thinning and loss are prominent aging phenotypes but have an unknown mechanism. We show that hair follicle stem cell (HFSC) aging causes the stepwise miniaturization of hair follicles and eventual hair loss in wild-type mice and in humans. In vivo fate analysis of HFSCs revealed that the DNA damage response in HFSCs causes proteolysis of type XVII collagen (COL17A1/BP180), a critical molecule for HFSC maintenance, to trigger HFSC aging, characterized by the loss of stemness signatures and by epidermal commitment. Aged HFSCs are cyclically eliminated from the skin through terminal epidermal differentiation, thereby causing hair follicle miniaturization. The aging process can be recapitulated by Col17a1 deficiency and prevented by the forced maintenance of COL17A1 in HFSCs, demonstrating that COL17A1 in HFSCs orchestrates the stem cell-centric aging program of the epithelial mini-organ.
The authors' abstract, as published at the source. Science, 2016 · DOI ↗
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Field: Urology
UrologyMedicine