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PLoS ONE· 2012Q1

Childhood Adversity and Epigenetic Modulation of the Leukocyte Glucocorticoid Receptor: Preliminary Findings in Healthy Adults

Audrey R. Tyrka, Lawrence H. Price, Carmen J. Marsit, Oakland C. Walters et al.

Short summary

Childhood adversity, including parental loss and maltreatment, is linked to increased methylation of the NR3C1 gene promoter in leukocytes (p<.05) and attenuated cortisol responses to the Dex/CRH test (p<.05) in healthy adults.

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Field: Behavioral Neuroscience

Behavioral NeuroscienceNeuroscience