Science· 2013Q1
Sleep Drives Metabolite Clearance from the Adult Brain
- 5,344citations
- Q1SCImago
- 2013year
Short summary
Natural sleep or anesthesia in mice increases the interstitial space in the brain by 60%, significantly enhancing the clearance of metabolic waste products like beta-amyloid.
AI-generated from the title and abstract; the full text is not read.
Key points
- Brain interstitial space expands by 60% during natural sleep or anesthesia in mice.
- This expansion increases convective exchange between cerebrospinal fluid and interstitial fluid.
- Enhanced fluid exchange accelerates the clearance rate of beta-amyloid.
- Sleep may be essential for removing neurotoxic waste products that accumulate while awake.
AI-generated from the title and abstract; the full text is not read.
Abstract
The conservation of sleep across all animal species suggests that sleep serves a vital function. We here report that sleep has a critical function in ensuring metabolic homeostasis. Using real-time assessments of tetramethylammonium diffusion and two-photon imaging in live mice, we show that natural sleep or anesthesia are associated with a 60% increase in the interstitial space, resulting in a striking increase in convective exchange of cerebrospinal fluid with interstitial fluid. In turn, convective fluxes of interstitial fluid increased the rate of β-amyloid clearance during sleep. Thus, the restorative function of sleep may be a consequence of the enhanced removal of potentially neurotoxic waste products that accumulate in the awake central nervous system.
The authors' abstract, as published at the source. Science, 2013 · DOI ↗
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Field: Cognitive Neuroscience
Cognitive NeuroscienceNeuroscience