PubMed· 2013
Frequency Dependence of Signal Power and Spatial Reach of the Local Field Potential
- 3,658citations
- 2013year
Short summary
In normal monkeys, basal ganglia (GP) neurons show independent activity, unlike cortical and thalamic neurons which are driven by common inputs. Parkinsonian symptoms induced by MPTP treatment cause many GP neurons to become oscillatory and exhibit correlated activity.
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Key points
- 93.8% of globus pallidus (GP) neuron pairs in normal monkeys showed independent activity.
- Cortical and thalamic neurons, in contrast, are driven by common inputs.
- MPTP treatment induced parkinsonian signs and tremor in the monkey.
- After MPTP, 35% of GP neurons became oscillatory, and 19% of GP pairs showed oscillatory cross-correlograms.
AI-generated from the title and abstract; the full text is not read.
Abstract
1. To test the mode of functional connectivity in the basal ganglia circuitry, we studied the activity of simultaneously recorded neurons in the globus pallidus (GP) of a behaving rhesus monkey. The cross-correlograms of pairs of neurons in the GP were compared with those of neurons in the thalamus and frontal cortex and to the cross-correlograms of pallidal pairs after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment. 2. In contrast with cortical and thalamic neuronal activity, almost all pairs (n = 76/81 pairs; 93.8%, 1,629/1,651 histograms; 98.7%) of GP neurons in the normal monkey were not driven by a common input. 3. The monkey was systemically treated with MPTP until the appearance of parkinsonian signs and an intermittent 7- to 11-Hz action/postural tremor. After the MPTP treatment, many pallidal neurons (49/140; 35%) became oscillatory, and 19% (n = 31/162) of pallidal pairs had oscillatory cross-correlograms. 4. These results support the model of parallel processing in the basal ganglia of normal monkeys and suggest a breakdown of the independent activity in the parkinsonian state.
The authors' abstract, as published at the source. PubMed, 2013 · DOI ↗
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Field: Cognitive Neuroscience
Cognitive NeuroscienceNeuroscience