Science· 2025Q1
Clinically ready magnetic microrobots for targeted therapies
- 85citations
- Q1SCImago
- 2025year
Short summary
A magnetically guided microrobotic platform navigates precisely within human vasculature models and large animal models under physiological conditions, enabling targeted drug delivery.
AI-generated from the title and abstract; the full text is not read.
Key points
- Developed a magnetically guided microrobotic drug delivery platform.
- Platform integrates clinical electromagnetic navigation, a custom release catheter, and a dissolvable capsule.
- Demonstrated precise navigation in human vasculature models in vitro.
- Confirmed successful tracking and navigation in large animal models in vivo under fluoroscopy.
AI-generated from the title and abstract; the full text is not read.
Abstract
Systemic drug administration often causes off-target effects, limiting the efficacy of advanced therapies. Targeted drug delivery approaches increase local drug concentrations at the diseased site while minimizing systemic drug exposure. We present a magnetically guided microrobotic drug delivery platform capable of precise navigation under physiological conditions. This platform integrates a clinical electromagnetic navigation system, a custom-designed release catheter, and a dissolvable capsule for accurate therapeutic delivery. In vitro tests showed precise navigation in human vasculature models, and in vivo experiments confirmed tracking under fluoroscopy and successful navigation in large animal models. The microrobot balances magnetic material concentration, contrast agent loading, and therapeutic drug capacity, offering a promising solution for precise targeted drug delivery.
The authors' abstract, as published at the source. Science, 2025 · DOI ↗
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Field: Condensed Matter Physics
Condensed Matter PhysicsPhysics and Astronomy