Biomedical Optics Express· 2013Q1
High-resolution, lensless endoscope based on digital scanning through a multimode optical fiber
- 336citations
- Q1SCImago
- 2013year
Short summary
A 450 μm diameter endoscope uses digital phase conjugation to focus and scan laser light through a passive multimode fiber, achieving sub-micron resolution for imaging neuronal cells.
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Key points
- An ultra-thin rigid endoscope with a 450 μm diameter was demonstrated.
- Digital phase conjugation was used to overcome modal scrambling in a passive multimode optical fiber.
- The system achieved sub-micron resolution and high-quality fluorescence imaging of neuronal cells.
- The endoscope's small diameter and image quality are suitable for minimally invasive medical imaging.
AI-generated from the title and abstract; the full text is not read.
Abstract
We propose and experimentally demonstrate an ultra-thin rigid endoscope (450 μm diameter) based on a passive multimode optical fiber. We use digital phase conjugation to overcome the modal scrambling of the fiber to tightly focus and scan the laser light at its distal end. By exploiting the maximum number of modes available, sub-micron resolution, high quality fluorescence images of neuronal cells were acquired. The imaging system is evaluated in terms of fluorescence collection efficiency, resolution and field of view. The small diameter of the proposed endoscope, along with its high quality images offer an opportunity for minimally invasive medical endoscopic imaging and diagnosis based on cellular phenotype via direct tissue penetration.
The authors' abstract, as published at the source. Biomedical Optics Express, 2013 · DOI ↗
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Field: Acoustics and Ultrasonics
Acoustics and UltrasonicsPhysics and Astronomy