Current Opinion in Neurobiology· 2026Q1· Review
Beyond AMPARs: Dynamic remodeling of the synaptic surface proteome during plasticity
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- Q1SCImago
- 2026year
Short summary
Synaptic plasticity involves dynamic remodeling of the entire synaptic surface proteome, not just AMPA receptors, with proteins like neuromodulatory receptors and cell adhesion molecules undergoing complex trafficking beyond classical recycling.
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Key points
- Synaptic plasticity involves dynamic remodeling of a broad range of synaptic membrane proteins, not solely AMPA receptors.
- Neuromodulatory receptors and cell adhesion molecules undergo complex trafficking and processing pathways.
- Endocytic fate decisions and local protein synthesis are key mechanisms influencing synaptic protein composition.
- These processes differ between presynaptic and postsynaptic compartments, contributing to distinct plasticity forms (LTP/LTD).
AI-generated from the title and abstract; the full text is not read.
Abstract
Activity-dependent changes in synaptic strength are widely studied through mechanisms involving AMPA receptor trafficking. However, increasing evidence indicates that a broader range of synaptic membrane proteins, including neuromodulatory receptors and cell adhesion molecules, also undergo dynamic remodeling during synaptic plasticity. These proteins engage diverse trafficking and processing pathways that extend beyond classical recycling mechanisms. In this review, we discuss recent advances in two key aspects of membrane protein dynamics: compartment-specific endocytic fate decisions and the processing and delivery of locally synthesized proteins. We highlight how these pathways differ between pre- and postsynaptic compartments and contribute to distinct forms of plasticity, including LTP and LTD. Finally, we discuss emerging approaches to study synaptic surface proteome remodeling at a systems level and outline key challenges for understanding how coordinated changes in membrane protein composition shape synaptic function and plasticity.
The authors' abstract, as published at the source. Current Opinion in Neurobiology, 2026 · DOI ↗
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Field: Cellular and Molecular Neuroscience
Cellular and Molecular NeuroscienceNeuroscience