Key papers in Cellular and Molecular Neuroscience
Pofolia’s corpus holds 54 papers from the Cellular and Molecular Neuroscience subfield (2012–2026). The list below starts with the most cited.
Most cited
Ranked by citation count. Because citations accumulate over time, this list naturally leans towards work published a few years ago; for where the field is now, see “recently added”.
Translational Findings on Brain-Derived Neurotrophic Factor and Anxiety: Contributions from Basic Research to Clinical Practice
Neuropsychobiology · 2013 · Q1 · SJR 1.00 · FWCI 114.40 · 4,008 citations
The BDNF Val(66)Met polymorphism is linked to anxiety disorders, with animal studies showing reduced BDNF secretion in specific genotypes correlating with anxiety.
Multiple Wearable Sensors in Parkinson and Huntington Disease Individuals: A Pilot Study in Clinic and at Home
Digital Biomarkers · 2017 · Q2 · FWCI 104.64 · 3,186 citations · Open access
Wearable sensors successfully captured objective activity data in individuals with Parkinson's and Huntington's disease, demonstrating feasibility and identifying significant differences in lying-down time compared to controls.
Small molecule drug screening in Drosophila identifies the 5HT2A receptor as a feeding modulation target
Scientific Reports · 2013 · Q1 · FWCI 106.35 · 2,320 citations · Open access
A high-throughput screen of 3630 small molecules in fruit fly larvae identified metitepine as a potent appetite suppressant, acting specifically through the 5HT2A receptor.
A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules
The Journal of Experimental Medicine · 2015 · Q1 · SJR 5.00 · FWCI 62.22 · 2,175 citations · Open access
Researchers have discovered a previously unknown lymphatic vessel network within the dura mater of the mouse brain that absorbs cerebrospinal fluid (CSF) and brain interstitial fluid (ISF). This dural lymphatic system directly drains these fluids into cervical lymph nodes.
Prevalence of Muscular Dystrophies: A Systematic Literature Review
Neuroepidemiology · 2014 · Q1 · SJR 1.00 · FWCI 21.83 · 2,052 citations · Open access
This systematic review found the combined prevalence of all muscular dystrophies to be between 19.8 and 25.1 per 100,000 person-years, with myotonic, Duchenne, and facioscapulohumeral dystrophies being the most common types.
Neurobiologic Advances from the Brain Disease Model of Addiction
New England Journal of Medicine · 2016 · Q1 · SJR 18.00 · FWCI 83.61 · 1,928 citations · Open access
Addiction is increasingly understood as a brain disease, supported by neurobiological findings on altered reward circuits, heightened cravings, and weakened executive functions, leading to more effective prevention and treatment strategies.
Hippocampal sharp wave‐ripple: A cognitive biomarker for episodic memory and planning
Hippocampus · 2015 · Q2 · SJR 1.00 · FWCI 40.53 · 1,890 citations · Open access
Hippocampal sharp wave-ripples (SPW-Rs), a synchronous brain pattern, are crucial for memory consolidation and planning by replaying neuronal sequences. Disrupting SPW-Rs impairs memory, and their pathological forms ('p-ripples') are linked to epilepsy, schizophrenia, and Alzheimer's.
Odorant Reception in Insects: Roles of Receptors, Binding Proteins, and Degrading Enzymes
Annual Review of Entomology · 2012 · Q1 · SJR 3.00 · FWCI 21.80 · 1,741 citations
Insect olfaction relies on odorant receptors (ORs), odorant-binding proteins (OBPs), and odorant-degrading enzymes (ODEs), with recent research deorphanizing ORs and revealing functions for OBPs and ODEs.
A GAL4-Driver Line Resource for Drosophila Neurobiology
Cell Reports · 2012 · Q1 · SJR 3.00 · FWCI 26.13 · 1,650 citations · Open access
Researchers have created a resource of 7,000 transgenic fruit fly lines where GAL4 expression is driven by specific genomic DNA fragments, allowing precise control over gene expression in distinct neuronal subsets.
Opposite Effects of mGluR1a and mGluR5 Activation on Nucleus Accumbens Medium Spiny Neuron Dendritic Spine Density
PLoS ONE · 2016 · Q1 · FWCI 71.80 · 1,630 citations · Open access
Activating different subtypes of group I metabotropic glutamate receptors (mGluR1a and mGluR5) in the nucleus accumbens (NAc) has opposing effects on dendritic spine density, with mGluR5 decreasing density and mGluR1a increasing it.
Impairment of paravascular clearance pathways in the aging brain
Annals of Neurology · 2014 · Q1 · SJR 3.00 · FWCI 21.73 · 1,501 citations
Aging in mice significantly impairs the brain's waste removal system, reducing the clearance of amyloid-beta by 40% in old mice compared to young ones.
Use of the Open Field Maze to Measure Locomotor and Anxiety-like Behavior in Mice
Journal of Visualized Experiments · 2015 · Q2 · FWCI 9.42 · 1,476 citations · Open access
A protocol for the Open Field Maze test demonstrates that Wild Type mice exhibit significantly less anxiety-related behaviors compared to Knock Out mice, while both strains show similar ambulatory ability.
Brain-Derived Neurotrophic Factor: A Key Molecule for Memory in the Healthy and the Pathological Brain
Frontiers in Cellular Neuroscience · 2019 · Q2 · SJR 1.00 · FWCI 47.83 · 1,413 citations · Open access
Brain-Derived Neurotrophic Factor (BDNF) plays a crucial role in learning and memory, with its expression levels varying significantly and being altered in aging and psychiatric conditions affecting memory structures like the hippocampus.
Liking, wanting, and the incentive-sensitization theory of addiction.
American Psychologist · 2016 · Q1 · SJR 2.00 · FWCI 38.02 · 1,403 citations
The incentive-sensitization theory proposes that addiction stems from an amplified "wanting" for rewards, driven by dopamine-related neural systems, rather than an increased "liking" of the reward itself.
Genetics of Parkinson's Disease
Cold Spring Harbor Perspectives in Medicine · 2012 · Q1 · SJR 3.00 · 1,388 citations · Open access
Fifteen years of research have identified several single-gene causes and numerous genetic risk factors for Parkinson's disease (PD). Monogenic forms, though rare, account for a significant portion of familial and sporadic cases.
Characteristics of the Cholecystokinin-Induced Depolarization of Pacemaking Activity in Cultured Interstitial Cells of Cajal from Murine Small Intestine
Cellular Physiology and Biochemistry · 2013 · Q3 · FWCI 24.73 · 1,384 citations · Open access
Cholecystokinin (CCK) depolarizes and reduces the amplitude of pacemaker potentials in cultured mouse intestinal cells (ICCs) via a CCK1 receptor and TRPC5 channel mechanism.
BDNF: A Key Factor with Multipotent Impact on Brain Signaling and Synaptic Plasticity
Cellular and Molecular Neurobiology · 2017 · Q1 · SJR 1.00 · FWCI 30.02 · 1,356 citations · Open access
Brain-derived neurotrophic factor (BDNF) plays a crucial role in neuronal development, neuroprotection, and synaptic plasticity, essential for cognition and memory. Its diverse effects stem from various active isoforms that interact with different receptors, activating multiple signaling pathways.
Cerebral Arterial Pulsation Drives Paravascular CSF–Interstitial Fluid Exchange in the Murine Brain
Journal of Neuroscience · 2013 · Q1 · SJR 1.00 · FWCI 17.01 · 1,350 citations · Open access
Cerebral arterial pulsation directly drives the flow of cerebrospinal fluid (CSF) into the brain along paravascular spaces, facilitating the clearance of waste products like amyloid-beta.
Brain-derived neurotrophic factor and its clinical implications
Archives of Medical Science · 2015 · Q2 · FWCI 10.34 · 1,340 citations · Open access
Brain-derived neurotrophic factor (BDNF) is crucial for neuronal survival, growth, and plasticity, impacting learning and memory. Its signaling pathways are also involved in regulating glucose metabolism and protecting pancreatic beta cells.
Annals of the New York Academy of Sciences
Annals of the New York Academy of Sciences · 2019 · Q1 · SJR 1.00 · 1,314 citations
Striatal astrocytes, abundant in the brain region most affected by Huntington's disease (HD), actively contribute to the disease's molecular pathology and related symptoms in mouse models.
Recently added
Oncology Reports
Oncology Reports · 2026 · Q2 · 211 citations
Prostate cancer and benign hyperplasia show high expression of BDNF and TrkB, while normal prostate tissue exhibits low expression of most neurotrophins and their receptors. The absence of p75 expression in cancerous and hyperplastic cells was also noted.
A draft human pangenome reference
Nature · 2023 · Q1 · SJR 19.00 · FWCI 134.73 · 1,166 citations · Open access
The first draft of a human pangenome reference, comprising 47 phased, diploid assemblies from diverse individuals, captures >99% of expected genome sequence with >99% accuracy and adds 119 million base pairs of euchromatic polymorphic sequences and 1,115 gene duplications compared to GRCh38.
Glymphatic failure as a final common pathway to dementia
Science · 2020 · Q1 · SJR 10.00 · FWCI 42.95 · 1,064 citations
Glymphatic system failure, which clears brain waste products, may be a final common pathway to dementia, linked to age-related sleep disruption.
A connectome and analysis of the adult Drosophila central brain
eLife · 2020 · Q1 · SJR 3.00 · FWCI 66.88 · 1,231 citations
Researchers mapped the neural circuitry of most of the adult fruit fly central brain, defining novel cell types and providing an exhaustive atlas of neurons and their chemical synapses.
Brain-Derived Neurotrophic Factor: A Key Molecule for Memory in the Healthy and the Pathological Brain
Frontiers in Cellular Neuroscience · 2019 · Q2 · SJR 1.00 · FWCI 47.83 · 1,413 citations · Open access
Brain-Derived Neurotrophic Factor (BDNF) plays a crucial role in learning and memory, with its expression levels varying significantly and being altered in aging and psychiatric conditions affecting memory structures like the hippocampus.
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