Journal of the International Neuropsychological Society· 2026Q2· Review
Cognitive outcomes following neurosurgery for frontal intracerebral tumors: A systematic review and meta-analysis
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- Q2SCImago
- 2026year
Short summary
Neurosurgical resection of frontal lobe tumors did not significantly alter cognitive performance post-surgery compared to pre-surgery baselines (n=15 studies).
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Key points
- Frontal lobe tumor resection did not lead to significant cognitive decline compared to pre-surgery performance.
- A meta-analysis of 15 studies quantitatively assessed cognitive effects.
- Significant limitations in current literature include assessment variability, inconsistent follow-up, and small sample sizes.
- Standardized assessments and larger cohorts are needed for better understanding of post-neurosurgical cognitive outcomes.
AI-generated from the title and abstract; the full text is not read.
Abstract
OBJECTIVE: Neurosurgical resection of frontal lobe tumors poses specific challenges to the patients. Even when lesions involve the so-called "non-eloquent" areas, such as the prefrontal cortex, neurosurgery can still affect critical functions, because the prefrontal regions are essential for executive functions and other complex cognitive processes. The aim of this study is to systematically review the literature and quantitatively assess the impact of frontal lobe tumor resection on patients' cognitive functioning. METHODS: = 15) including sufficient data to quantitatively evaluate the cognitive effects of frontal lobe tumor resections. RESULTS: We found that cognitive performance, after neurosurgery, was not significantly changed compared to pre-neurosurgery performance. We also identified several limitations in the literature, including variability in neuropsychological assessment protocols, differences in follow-up time points, inconsistent reporting of baseline cognitive functioning, and underpowered sample sizes. CONCLUSIONS: In future studies, researchers should adopt standardized, comprehensive assessments, with well-powered cohorts and long-term follow-ups, to better characterize post-neurosurgical cognitive outcomes, including those regarding "non-eloquent" frontal regions. A multidisciplinary and harmonized approach remains crucial for understanding the cognitive impact of frontal lobe tumor neurosurgery and for improving patient care.
The authors' abstract, as published at the source. Journal of the International Neuropsychological Society, 2026 · DOI ↗
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Field: Genetics (Medicine)
GeneticsMedicine