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The Journal of Organic Chemistry· 2026Q2

Visible-Light-Induced Synthesis for Sulfonyl (Thio)chromones and 4-Quinolones from 2-Alknyl Benzaldehydes and Sodium Sulfinates via a Cascade Sulfonylation/Cyclization/Isomerization Processes

Zhengyu Jiang, Zhaohui Xu, Qing‐Yan Liu, Junmin Chen

Short summary

A new visible-light photoredox reaction enables a one-pot synthesis of sulfonyl 4-(thio)chromones and 4-quinolones from 2-alkynyl benzaldehydes and sodium sulfinates.

AI-generated from the title and abstract; the full text is not read.

Key points

  • Visible-light photoredox reaction for synthesizing sulfonyl 4-(thio)chromones and 4-quinolones.
  • Employs 2-alkynyl benzaldehydes and sodium sulfinates as starting materials.
  • One-pot cascade process involves radical sulfonylation, cyclization, and isomerization.
  • Enables straightforward assembly of protecting-group-free sulfonyl 4-quinolones.
  • Protocol offers broad substrate scope and excellent functional group compatibility.

AI-generated from the title and abstract; the full text is not read.

Abstract

Abstract Herein, we report a visible-light-mediated photoredox reaction for the synthesis of sulfonyl 4-(thio)chromones and 4-quinolone derivatives. This transformation employs easily accessible 2-alkynyl benzaldehydes and sodium sulfinates as starting materials, enabling a one-pot cascade process involving radical sulfonylation, cyclization, and isomerization under mild conditions. Notably, this strategy allows the straightforward assembly of protecting-group-free sulfonyl 4-quinolones. Benefiting from its operational simplicity, broad substrate scope, and excellent functional group compatibility, this protocol provides a practical approach for the construction of valuable 4-(thio)chromones and 4-quinolone derivatives with potential biological and synthetic applications

The authors' abstract, as published at the source. The Journal of Organic Chemistry, 2026 · DOI ↗

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Field: Organic Chemistry

Organic ChemistryChemistry