Key papers in Organic Chemistry

Pofolia’s corpus holds 88 papers from the Organic Chemistry subfield (2012–2025). The list below starts with the most cited.

Most cited

Ranked by citation count. Because citations accumulate over time, this list naturally leans towards work published a few years ago; for where the field is now, see “recently added”.

• CRC Handbook of Chemistry and Physics

  2014 · FWCI 245.31 · 57,892 citations

  The 95th edition of the CRC Handbook of Chemistry and Physics has been released, continuing its legacy as a classic and highly respected scientific reference.

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• Visible Light Photoredox Catalysis with Transition Metal Complexes: Applications in Organic Synthesis

  Chemical Reviews · 2013 · Q1 · SJR 16.00 · FWCI 218.39 · 9,451 citations

  This review details the burgeoning field of visible light photoredox catalysis, highlighting how transition metal complexes can harness light energy to drive a wide array of organic transformations.

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• Free Radicals in Biology and Medicine

  Oxford University Press eBooks · 2015 · FWCI 172.00 · 8,905 citations

  This thoroughly revised edition offers a comprehensive account of the role of free radicals, reactive species (RS), and antioxidants in life, health, and disease.

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• In situ click chemistry generation of cyclooxygenase-2 inhibitors

  Nature Communications · 2017 · Q1 · SJR 4.00 · FWCI 252.60 · 7,562 citations · Open access

  Researchers developed a novel method using the cyclooxygenase-2 (COX-2) enzyme's active site as a reaction vessel to generate highly specific COX-2 inhibitors via in situ click chemistry.

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• Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals

  Journal of Medicinal Chemistry · 2014 · Q1 · SJR 1.00 · FWCI 69.81 · 6,286 citations

  Nitrogen heterocycles are crucial in drug design, with 59% of U.S. FDA-approved small-molecule drugs containing them.

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• Organic Photoredox Catalysis

  Chemical Reviews · 2016 · Q1 · SJR 16.00 · FWCI 366.49 · 6,221 citations

  This review highlights the diverse synthetic transformations enabled by organic photoredox catalysts, detailing their photophysical and electrochemical properties.

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• Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)

  Chemical Reviews · 2013 · Q1 · SJR 16.00 · FWCI 126.96 · 4,762 citations

  Over 20% of the top 200 drugs sold in 2011 contained fluorine, with a significant portion of new drug approvals featuring this element.

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• Synthetic Organic Electrochemical Methods Since 2000: On the Verge of a Renaissance

  Chemical Reviews · 2017 · Q1 · SJR 16.00 · FWCI 105.93 · 3,784 citations

  Synthetic organic electrochemistry has seen significant advances since 2000, moving towards a renaissance by enabling new molecular interactions and synthetic applications.

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• Self-assembly of block copolymers

  Chemical Society Reviews · 2012 · Q1 · SJR 11.00 · FWCI 74.72 · 3,550 citations

  Block copolymers (BCPs) self-assemble into diverse ordered structures like spheres, cylinders, and lamellae, offering potential applications across various fields.

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• Journal of Biological Chemistry

  Journal of Biological Chemistry · 2021 · Q1 · SJR 1.00 · 3,448 citations

  Biochemical assays reveal five distinct stages in the Hin-mediated DNA inversion reaction, from protein binding to DNA religation.

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• Photoredox Catalysis in Organic Chemistry

  The Journal of Organic Chemistry · 2016 · Q2 · FWCI 208.53 · 3,163 citations

  Photoredox catalysis uses visible light to drive chemical reactions by generating reactive intermediates through single-electron transfer, enabling novel reaction mechanisms.

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• Palladium‐Catalyzed Cross‐Coupling: A Historical Contextual Perspective to the 2010 Nobel Prize

  Angewandte Chemie International Edition · 2012 · Q1 · SJR 5.00 · FWCI 76.34 · 2,974 citations

  This review traces the historical origins and development of palladium-catalyzed cross-coupling reactions, which revolutionized C-C bond construction and earned Heck, Negishi, and Suzuki the 2010 Nobel Prize in Chemistry.

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• CH Bond Functionalization: Emerging Synthetic Tools for Natural Products and Pharmaceuticals

  Angewandte Chemie International Edition · 2012 · Q1 · SJR 5.00 · FWCI 122.00 · 2,966 citations

  Direct C-H bond functionalization is an emerging, powerful method for creating carbon-carbon and carbon-heteroatom bonds, offering an ideal route for synthesizing complex molecules.

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• Oxidative stress: a concept in redox biology and medicine

  Redox Biology · 2015 · Q1 · SJR 4.00 · FWCI 60.40 · 2,926 citations

  The concept of 'oxidative stress,' formulated in 1985, has become a widely used term in biology and medicine, with over 138,000 PubMed entries by 2015.

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• Applications of Palladium-Catalyzed C–N Cross-Coupling Reactions

  Chemical Reviews · 2016 · Q1 · SJR 16.00 · FWCI 182.33 · 2,905 citations

  Palladium-catalyzed C-N cross-coupling reactions are now essential for synthesizing anilines and derivatives, driven by the development of versatile catalysts and user-friendly conditions.

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• Cu and Cu-Based Nanoparticles: Synthesis and Applications in Catalysis

  Chemical Reviews · 2016 · Q1 · SJR 16.00 · FWCI 200.75 · 2,890 citations

  This review details the synthesis and diverse catalytic applications of copper (Cu) and Cu-based nanoparticles, highlighting their earth-abundant nature and tunable properties.

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• Ruthenium(II)-Catalyzed C–H Bond Activation and Functionalization

  Chemical Reviews · 2012 · Q1 · SJR 16.00 · FWCI 123.33 · 2,723 citations

  This review consolidates recent advancements in ruthenium(II)-catalyzed C–H bond activation and functionalization, highlighting its versatility in organic synthesis.

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• Dual Catalysis Strategies in Photochemical Synthesis

  Chemical Reviews · 2016 · Q1 · SJR 16.00 · FWCI 214.50 · 2,686 citations

  This review summarizes dual-catalyst strategies that combine photocatalysis with other catalytic systems to achieve novel bond constructions in organic synthesis.

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• Solar Synthesis: Prospects in Visible Light Photocatalysis

  Science · 2014 · Q1 · SJR 10.00 · FWCI 105.56 · 2,574 citations

  Transition metal chromophores, previously used for solar energy conversion, can now harness visible light for organic synthesis, overcoming the limitations of UV-only activation.

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• Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design

  Journal of Medicinal Chemistry · 2018 · Q1 · SJR 1.00 · FWCI 82.30 · 2,565 citations

  Fluorine's unique electronic properties and small size make it a versatile bioisostere, enabling substitution for various atoms and functional groups to enhance drug properties like potency and metabolism.

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Recently added

• Advances in Peptidomimetics for Next-Generation Therapeutics: Strategies, Modifications, and Applications

  Chemical Reviews · 2025 · Q1 · SJR 16.00 · FWCI 37.02 · 63 citations

  Peptidomimetics, engineered to overcome the limitations of natural peptides, are revolutionizing drug development with enhanced stability, specificity, and bioavailability.

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• Metallaphotoredox: The Merger of Photoredox and Transition Metal Catalysis

  Chemical Reviews · 2021 · Q1 · SJR 16.00 · FWCI 105.55 · 1,714 citations

  Metallaphotoredox catalysis, merging photoredox and transition metal catalysis, has emerged as a powerful tool for molecule construction by enabling photocatalytic substrate activation and novel activation modes of organometallic intermediates.

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• Direct Photocatalyzed Hydrogen Atom Transfer (HAT) for Aliphatic C–H Bonds Elaboration

  Chemical Reviews · 2021 · Q1 · SJR 16.00 · FWCI 74.18 · 1,294 citations

  Direct photocatalyzed hydrogen atom transfer (HAT) enables the elaboration of aliphatic C–H bonds, a long-standing challenge in organic synthesis.

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• Analytical Methods Used in Determining Antioxidant Activity: A Review

  International Journal of Molecular Sciences · 2021 · Q1 · SJR 1.00 · FWCI 111.03 · 1,986 citations · Open access

  This review critically presents key chemical assays for determining antioxidant activity, including ORAC, HORAC, TRAP, TOSC (hydrogen atom transfer), CUPRAC, FRAP, Folin-Ciocalteu (electron transfer), and ABTS, DPPH (mixed transfer).

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• Journal of Biological Chemistry

  Journal of Biological Chemistry · 2021 · Q1 · SJR 1.00 · 3,448 citations

  Biochemical assays reveal five distinct stages in the Hin-mediated DNA inversion reaction, from protein binding to DNA religation.

  Go to source →

Other subfields in the same field

• Analytical Chemistry
• Electrochemistry
• Physical and Theoretical Chemistry
• Inorganic Chemistry
• Spectroscopy

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