iScience· 2026Q1
OGT regulates RNA-binding protein nucleocytoplasmic partitioning, but this fails in amyotrophic lateral sclerosis
- 0citations
- Q1SCImago
- 2026year
Short summary
O-GlcNAcylation by OGT controls the location of RNA-binding proteins (RBPs) between the nucleus and cytoplasm, but this regulation is disrupted in amyotrophic lateral sclerosis (ALS).
AI-generated from the title and abstract; the full text is not read.
Key points
- OGT-mediated O-GlcNAcylation controls the localization of RBPs between the nucleus and cytoplasm.
- This regulatory mechanism is disrupted in the context of amyotrophic lateral sclerosis (ALS).
- The study includes original Western blot images to support all experimental results.
AI-generated from the title and abstract; the full text is not read.
Abstract
Original Western blot images are provided for all experiments shown in the manuscript. Where membranes were physically sectioned prior to antibody incubation to enable probing with different antibodies, the original images of the corresponding membrane sections are shown.
The authors' abstract, as published at the source. iScience, 2026 · DOI ↗
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Field: Neurology (Medicine)
NeurologyMedicine