Cell Regeneration· 2026Q1
Liver regeneration governed by zonated PIEZO1 mechanotransduction
- 0citations
- Q1SCImago
- 2026year
Short summary
DPP4-positive zone 2 hepatocytes sense mechanical stress via PIEZO1, triggering liver regeneration through NFATC3-dependent IGFBP2 expression.
AI-generated from the title and abstract; the full text is not read.
Key points
- Zone 2 hepatocytes expressing DPP4 are identified as the primary mechanosensory population in the liver.
- Mechanical stress activates the PIEZO1 channel in these hepatocytes.
- PIEZO1 activation leads to NFATC3-dependent expression of IGFBP2.
- This pathway explains why liver regeneration originates from the mid-lobule.
AI-generated from the title and abstract; the full text is not read.
Abstract
Abstract Mechanical forces are recognized as regulators of organ development, homeostasis, and regeneration, yet how physical cues are sensed in a region-specific manner within the liver remains unclear. In a Science article, Zhang and colleagues identify DPP4-positive zone 2 hepatocytes as a mechanosensory population, demonstrating that mechanical stress triggers the regenerative response through PIEZO1-mediated mechanotransduction. PIEZO1 activation in these cells induces NFATC3-dependent IGFBP2 expression, establishing a molecular link between tissue mechanics and spatially coordinated proliferation. This work provides a mechanistic explanation for why regeneration originates from the mid-lobule and introduces a druggable mechanotransduction axis that might be enhanced to accelerate liver repair.
The authors' abstract, as published at the source. Cell Regeneration, 2026 · DOI ↗
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Field: Hepatology
HepatologyMedicine