Stem Cell Research & Therapy· 2026Q1

A 2D‑3D culture transition enhances hepatic maturation of human mesenchymal stem cell-derived hepatocyte-like cells

Yanrong Yu, Siming Chen, Jian Bi, Dan Luo et al.

0citations
Q1SCImago
2026year

Short summary

Shifting human mesenchymal stem cell (hMSC) differentiation from 2D to 3D culture significantly enhances hepatic maturation, evidenced by reduced fetal markers (AFP) and transcriptomic similarity to primary human hepatocytes.

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Field: Hepatology

HepatologyMedicine