JACC Basic to Translational Science· 2026Q1
Left Ventricular Structural, Physiological, and Transcriptomic Abnormalities in a Novel Porcine Hypertrophic Cardiomyopathy Model
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- Q1SCImago
- 2026year
Short summary
A new porcine model of hypertrophic cardiomyopathy (HCM) exhibits structural, physiological, and transcriptomic abnormalities, demonstrating that the cardiac myosin inhibitor MYK-581 reduces hypercontractility and improves diastolic function.
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Key points
- A novel porcine model replicates structural, physiological, and transcriptomic abnormalities of HCM.
- The model strengthens the mechanistic link between genetic variants and HCM phenotypes.
- The cardiac myosin inhibitor MYK-581 reduced hypercontractility in the model.
- MYK-581 improved diastolic function in the porcine HCM model.
AI-generated from the title and abstract; the full text is not read.
Abstract
sensitivity. The cardiac myosin inhibitor MYK-581 reduced hypercontractility and improved diastolic function. Data from this large animal genetic model of HCM strengthen the mechanistic link between genetic variants and in vivo phenotypes and elucidate the mechanisms of myofilament-targeted therapies.
The authors' abstract, as published at the source. JACC Basic to Translational Science, 2026 · DOI ↗
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Field: Cardiology and Cardiovascular Medicine
Cardiology and Cardiovascular MedicineMedicine