Current Issues in Molecular Biology· 2025Q2· Review
Oxidative Stress in Aquaculture: Pathogenic Mechanisms and Preventive Strategies in Farmed Aquatic Animals
- 53citations
- Q2SCImago
- 2025year
Short summary
Oxidative stress, caused by an imbalance of reactive oxygen species (ROS), is a major driver of disease in farmed aquatic animals, leading to organ damage, inflammation, and impaired immunity.
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Key points
- Oxidative stress is a key factor in the pathogenesis of diseases affecting multiple organs in farmed aquatic animals.
- Mechanisms include excessive ROS leading to lipid peroxidation, inflammation, and mitochondrial dysfunction.
- Commonly affected systems include liver/pancreas, gills, muscle, skin/shell, metabolism, immunity, and reproduction.
- Preventive strategies involve nutritional antioxidants (vitamins, plant extracts), environmental regulation, and feed additives.
AI-generated from the title and abstract; the full text is not read.
Abstract
Oxidative stress (OS), defined as a disturbance in the balance between the production and elimination of reactive oxygen species (ROS), has been widely recognized as a key factor in the pathogenesis of various aquatic animal diseases. With the intensification of aquaculture and increasing environmental pressure, aquatic animals are frequently subjected to stressors that trigger oxidative stress, thereby compromising their health and productivity. This review comprehensively summarizes recent advances in understanding the involvement of oxidative stress in multiple organ-related diseases in farmed aquatic animals, including hepatic/pancreatic injuries, gill lesions, muscle degeneration, skin and shell disorders, metabolic disruptions, immunosuppression, and reproductive impairments. The underlying mechanisms involve excessive ROS-induced lipid peroxidation, inflammation, mitochondrial dysfunction, and the disruption of critical signaling pathways. Additionally, recent advances in nutritional antioxidants (e.g., vitamins, plant extracts), environmental regulation, and feed additives for mitigating oxidative damage are also discussed. A comprehensive understanding of the pathogenesis and regulation of oxidative stress is essential for improving aquatic animal health and enhancing the sustainability of aquaculture systems.
The authors' abstract, as published at the source. Current Issues in Molecular Biology, 2025 · DOI ↗
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ImmunologyImmunology and Microbiology