International Journal of Molecular Sciences· 2026Q1
Dihydromyricetin and Neuroinflammation: Implications for CNS Disorders and Therapeutic Development
- 0citations
- Q1SCImago
- 2026year
Short summary
Dihydromyricetin (DHM), a natural polyphenol, effectively crosses the blood-brain barrier and modulates neuroinflammation via NF-κB suppression and NLRP3 inflammasome inhibition, showing promise for Alzheimer's, Parkinson's, and stroke.
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Key points
- Dihydromyricetin (DHM) crosses the blood-brain barrier to exert effects in the central nervous system.
- DHM's neuroinflammatory modulation involves NF-κB suppression and NLRP3 inflammasome inhibition.
- DHM also regulates autophagy and impacts oxidative stress, ferroptosis, neurotrophic signaling, and gut-CNS communication.
- These mechanisms position DHM as a candidate therapeutic for neuroinflammatory CNS disorders such as Alzheimer's, Parkinson's, and stroke.
AI-generated from the title and abstract; the full text is not read.
Abstract
Dihydromyricetin (DHM) is a bioactive polyphenol with broad therapeutic potential, including strong anti-inflammatory activity. Importantly, DHM has been shown to cross the blood–brain barrier (BBB), enabling pharmacological activity within the central nervous system (CNS) and positioning it as a candidate for CNS disorders in which neuroinflammation plays a central role, including Alzheimer’s disease, Parkinson’s disease, and stroke. Therapeutics such as DHM, which address neuroinflammation, are of increasing interest. Across CNS disease models, DHM’s effects show recurring convergence on NF-κB suppression, NLRP3 inflammasome inhibition, and autophagy regulation, alongside context-specific mechanisms involving oxidative stress, ferroptosis, neurotrophic signaling, and peripheral gut–CNS communication. This review examines the evidence for DHM as a neuroinflammatory modulator, focusing on the mechanisms by which it exerts its therapeutic effects. By doing so, we aim to support its translational potential as a natural product for improving human health.
The authors' abstract, as published at the source. International Journal of Molecular Sciences, 2026 · DOI ↗
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Field: Complementary and alternative medicine
Complementary and alternative medicineMedicine