Foods· 2026Q1
Nicotinamide Mononucleotide-Producing Probiotic Strain B12-N Attenuates Aging and Cognitive Decline in a Caenorhabditis elegans Model of Alzheimer’s Disease: Efficacy and Underlying Mechanisms
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- Q1SCImago
- 2026year
Short summary
The probiotic strain Ligilactobacillus salivarius B12-N, which produces nicotinamide mononucleotide (NMN), attenuated aging and cognitive decline in a Caenorhabditis elegans model of Alzheimer's disease, showing comparable effects to purified NMN.
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Key points
- The probiotic strain Ligilactobacillus salivarius B12-N produces 6.25 μg of NMN per 10^9 CFU.
- B12-N attenuated aging and cognitive decline in a C. elegans Alzheimer's disease model.
- B12-N showed comparable efficacy to purified NMN across most tested aging and Alzheimer's-related phenotypes.
- Transcriptome analysis revealed overlapping pathway enrichments between B12-N and NMN, notably in P450 metabolism, longevity regulation, and autophagy.
AI-generated from the title and abstract; the full text is not read.
Abstract
Nicotinamide mononucleotide (NMN) is an active component found in probiotics that may help alleviate Alzheimer’s disease and the effects of aging. The screened NMN-producing strain, Ligilactobacillus salivarius B12-N, contained 6.25 μg of NMN per 109 CFU, as determined by LC–MS analysis of bacterial cell extracts. The results indicate that B12-N showed a slightly greater numerical improvement in chemotactic behavior than purified NMN. However, no significant differences were observed between B12-N and NMN in other AD-related or aging-associated phenotypes examined. Transcriptome analysis revealed that 16 pathways were common to both the NMN group and the B12-N group. Notably, the P450 metabolism pathway, longevity regulation pathway, and autophagy pathway were significantly enriched. These findings indicate partially overlapping phenotypic and transcriptomic responses to B12-N and NMN, suggesting that NMN may contribute to some of the biological effects associated with B12-N.
The authors' abstract, as published at the source. Foods, 2026 · DOI ↗
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AgingBiochemistry, Genetics and Molecular Biology