Science· 2012Q1
A High-Coverage Genome Sequence from an Archaic Denisovan Individual
- 2,137citations
- Q1SCImago
- 2012year
Short summary
Researchers developed a new DNA library preparation method to sequence a Denisovan genome at 30x coverage, revealing extremely low genetic diversity in this extinct human relative.
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Key points
- A new DNA library preparation method achieved 30x genome coverage for an archaic Denisovan individual.
- The Denisovan genome reveals extremely low heterozygosity, suggesting very low genetic diversity.
- The high-quality sequence allows for direct estimation of admixture with modern humans.
- The genome provides a catalog of genetic changes in modern humans since divergence from Denisovans.
AI-generated from the title and abstract; the full text is not read.
Abstract
We present a DNA library preparation method that has allowed us to reconstruct a high-coverage (30×) genome sequence of a Denisovan, an extinct relative of Neandertals. The quality of this genome allows a direct estimation of Denisovan heterozygosity indicating that genetic diversity in these archaic hominins was extremely low. It also allows tentative dating of the specimen on the basis of "missing evolution" in its genome, detailed measurements of Denisovan and Neandertal admixture into present-day human populations, and the generation of a near-complete catalog of genetic changes that swept to high frequency in modern humans since their divergence from Denisovans.
The authors' abstract, as published at the source. Science, 2012 · DOI ↗
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Field: Anthropology
AnthropologySocial Sciences