npj Biofilms and Microbiomes· 2026Q1
Environmental cues shape mucosal enteric glia networks independent of lamina propria innervation
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- Q1SCImago
- 2026year
Short summary
Mucosal enteric glia network organization is drastically impacted by diet and gut microbiota, independent of nerve fiber density, with colitis causing significant changes and germ-free mice showing reduced glial numbers.
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Key points
- Colitis drastically impacts glial network organization in the lamina propria.
- Diet modulates mucosal glia cyto-architecture, and microbiota induces region-specific variations.
- Germ-free mice exhibit reduced mucosal glia numbers throughout the intestine, which can be restored by conventionalization.
- Vagotomy affects mucosal enteric glia maintenance in a diet-dependent manner but does not influence lamina propria colonization.
- Differences in nerve fiber density do not explain variations in mucosal enteric glia networks.
AI-generated from the title and abstract; the full text is not read.
Abstract
Abstract Mucosal enteric glia are implicated in different aspects of gut function but the determinants of their occupancy of the lamina propria remain obscure. Analyzing mucosal enteric glia during intestinal inflammation and in mouse models differing for diet and gut microbiota, we found that colitis drastically impacts glial network organization, and that diet modulates mucosal glia cyto-architecture, with microbiota inducing intestinal region-specific variations. Restored by conventionalization, germ-free mice exhibit reduced mucosal glia numbers throughout the intestine. Vagotomy affects mucosal enteric glia maintenance in a diet-dependent fashion but does not influence lamina propria colonization. Also, differences in nerve fiber density fail to account for the variations in mucosal enteric glia networks. Providing insight into their interaction with neuronal components and the luminal milieu, our results emphasize the profound plasticity of enteric glia, and suggest that their presence in the mucosa is not merely configured by lamina propria innervation.
The authors' abstract, as published at the source. npj Biofilms and Microbiomes, 2026 · DOI ↗
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Field: Gastroenterology
GastroenterologyMedicine