Key papers in Gastroenterology
Pofolia’s corpus holds 60 papers from the Gastroenterology subfield (2012–2021). The list below starts with the most cited.
Most cited
Ranked by citation count. Because citations accumulate over time, this list naturally leans towards work published a few years ago; for where the field is now, see “recently added”.
Rome III functional constipation and irritable bowel syndrome with constipation are similar disorders within a spectrum of sensitization, regulated by serotonin.
IRIS Research product catalog (Sapienza University of Rome) · 2013 · FWCI 256.67 · 2,747 citations
Functional constipation (FC) and irritable bowel syndrome with constipation (IBS-C) are not distinct disorders but rather lie on a spectrum of visceral sensitivity modulated by serotonin signaling.
The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems.
PubMed · 2015 · FWCI 64.27 · 2,594 citations
The gut-brain axis involves bidirectional communication between the gut and brain, with gut microbiota playing a crucial role in influencing these interactions through neural, endocrine, immune, and humoral pathways.
The Chicago Classification of esophageal motility disorders, v3.0
Neurogastroenterology & Motility · 2014 · Q1 · SJR 1.00 · FWCI 79.56 · 1,959 citations · Open access
The Chicago Classification (CC) for esophageal motility disorders has been updated to v3.0, introducing a hierarchical diagnostic approach and incorporating new criteria for evaluating esophagogastric junction (EGJ) morphology and contractility.
Update on the epidemiology of gastro-oesophageal reflux disease: a systematic review
Gut · 2013 · Q1 · SJR 8.00 · FWCI 12.81 · 1,927 citations
A systematic review of population-based studies reveals that gastro-oesophageal reflux disease (GERD) is prevalent worldwide, with a statistically significant increase in prevalence observed since 1995, particularly in North America and East Asia.
Guidelines for the Diagnosis and Management of Gastroesophageal Reflux Disease
The American Journal of Gastroenterology · 2013 · Q1 · SJR 2.00 · FWCI 91.33 · 1,767 citations
This guideline provides updated recommendations for diagnosing and managing gastroesophageal reflux disease (GERD), a common condition affecting 10-20% of the Western world's population.
The Oslo definitions for coeliac disease and related terms
Gut · 2012 · Q1 · SJR 8.00 · FWCI 74.23 · 1,704 citations · Open access
A multidisciplinary task force has established standardized definitions for coeliac disease (CD) and related terms to address a lack of consensus in the literature.
Dysbiosis of the gut microbiota in disease
Microbial Ecology in Health and Disease · 2015 · FWCI 59.43 · 1,702 citations
Growing evidence links gut microbiota dysbiosis to the development of both intestinal and extra-intestinal diseases.
ACG Clinical Guidelines: Diagnosis and Management of Celiac Disease
The American Journal of Gastroenterology · 2013 · Q1 · SJR 2.00 · FWCI 93.21 · 1,679 citations
This guideline provides updated recommendations for diagnosing and managing celiac disease, an immune reaction to gluten that has seen a significant rise in prevalence and diagnosis rates over the past 50 and 10 years, respectively.
Pediatric Gastroesophageal Reflux Clinical Practice Guidelines
Journal of Pediatric Gastroenterology and Nutrition · 2018 · Q1 · FWCI 77.98 · 1,533 citations
Updated clinical guidelines for diagnosing and managing gastroesophageal reflux disease (GERD) in infants and children have been formulated by NASPGHAN and ESPGHAN, incorporating evidence up to June 2015.
Modern diagnosis of GERD: the Lyon Consensus
Gut · 2018 · Q1 · SJR 8.00 · FWCI 90.33 · 1,441 citations · Open access
The Lyon Consensus redefines GERD diagnosis by establishing specific criteria for conclusive evidence, moving beyond symptom-based assessments alone.
Gut microbes promote colonic serotonin production through an effect of short‐chain fatty acids on enterochromaffin cells
The FASEB Journal · 2014 · Q1 · SJR 1.00 · FWCI 22.61 · 1,289 citations
Gut microbes significantly increase colonic serotonin production in mice by promoting the expression of Tph1, the rate-limiting enzyme for serotonin synthesis, via short-chain fatty acids acting on enterochromaffin cells.
European Society Paediatric Gastroenterology, Hepatology and Nutrition Guidelines for Diagnosing Coeliac Disease 2020
Journal of Pediatric Gastroenterology and Nutrition · 2019 · Q1 · FWCI 71.84 · 1,181 citations · Open access
Updated guidelines allow for accurate coeliac disease diagnosis in children with or without duodenal biopsies, simplifying the diagnostic pathway.
Spectrum of gluten-related disorders: consensus on new nomenclature and classification
BMC Medicine · 2012 · Q1 · SJR 2.00 · FWCI 62.02 · 1,144 citations · Open access
A decade ago, celiac disease was rare and ignored; now, it's globally recognized, fueling a $2.5 billion gluten-free market. This review proposes new nomenclature and classification for gluten reactions, including allergic, autoimmune, and possibly immune-mediated forms.
Clinical Guideline: Management of Gastroparesis
The American Journal of Gastroenterology · 2012 · Q1 · SJR 2.00 · FWCI 27.82 · 1,138 citations
New clinical guidelines offer a structured approach to managing gastroparesis, emphasizing nutritional assessment, symptom relief, and glycemic control, while noting current treatments are inadequate.
Diagnosis and management of adult coeliac disease: guidelines from the British Society of Gastroenterology
Gut · 2014 · Q1 · SJR 8.00 · FWCI 60.49 · 1,116 citations · Open access
New guidelines from the British Society of Gastroenterology offer updated recommendations for diagnosing and managing adult coeliac disease, drawing on a multidisciplinary panel's review of existing literature.
Irritable Bowel Syndrome
JAMA · 2015 · Q1 · SJR 5.00 · FWCI 61.41 · 1,105 citations
Irritable Bowel Syndrome (IBS) is a symptom cluster arising from diverse pathologies, not a single disease, and its diagnosis relies on symptom identification and exclusion of other conditions.
Celiac disease: a comprehensive current review
BMC Medicine · 2019 · Q1 · SJR 2.00 · FWCI 73.06 · 1,092 citations · Open access
Celiac disease, affecting approximately 1% of the population, is an autoimmune disorder triggered by gluten, with genetic predisposition and environmental factors playing key roles. While a strict gluten-free diet is the current sole treatment, research is exploring alternative therapies.
Evaluation and Treatment of Functional Constipation in Infants and Children
Journal of Pediatric Gastroenterology and Nutrition · 2013 · Q1 · FWCI 29.46 · 1,086 citations
New evidence-based guidelines offer standardized recommendations for evaluating and treating functional constipation in children, aiming to improve care quality.
Esophageal motility disorders on high‐resolution manometry: Chicago classification version 4.0<sup>©</sup>
Neurogastroenterology & Motility · 2020 · Q1 · SJR 1.00 · FWCI 65.07 · 1,027 citations · Open access
The updated Chicago Classification v4.0 (CCv4.0) provides more rigorous and expansive criteria for diagnosing esophageal motility disorders using high-resolution manometry (HRM). It incorporates new testing positions, refined definitions for obstruction, and stricter diagnostic criteria to reduce ambiguity.
European Society for the Study of Coeliac Disease (ESsCD) guideline for coeliac disease and other gluten‐related disorders
United European Gastroenterology Journal · 2019 · Q1 · SJR 2.00 · FWCI 67.26 · 995 citations · Open access
This guideline provides updated recommendations for diagnosing and managing coeliac disease (CD) and other gluten-related disorders in adults and children. It emphasizes timely diagnosis on a gluten-containing diet and highlights the primary treatment of a strict gluten-free diet.
Recently added
ACG Clinical Guideline for the Diagnosis and Management of Gastroesophageal Reflux Disease
The American Journal of Gastroenterology · 2021 · Q1 · SJR 2.00 · FWCI 83.26 · 942 citations
Updated guidelines offer evidence-based recommendations for GERD diagnosis and management, addressing evolving diagnostic tools, increased scrutiny of PPI safety, and emerging surgical/endoscopic interventions.
The Gut–Brain Axis
Annual Review of Medicine · 2021 · Q1 · SJR 6.00 · FWCI 58.42 · 741 citations · Open access
Bidirectional communication between the gut, brain, and microbiome is established, involving identified signaling molecules and channels, but its causative role in disorders like IBS remains unclear.
ACG Clinical Guideline: Upper Gastrointestinal and Ulcer Bleeding
The American Journal of Gastroenterology · 2021 · Q1 · SJR 2.00 · FWCI 53.97 · 599 citations
New ACG guidelines suggest discharging very-low-risk upper GI bleeding patients (Glasgow-Blatchford score 0-1) from the ED, transfusing red blood cells at a 7 g/dL threshold, and administering erythromycin before endoscopy within 24 hours.
Endoscopic diagnosis and management of nonvariceal upper gastrointestinal hemorrhage (NVUGIH): European Society of Gastrointestinal Endoscopy (ESGE) Guideline – Update 2021
Endoscopy · 2021 · Q2 · FWCI 58.42 · 595 citations · Open access
The ESGE recommends using the Glasgow-Blatchford Score (GBS) for pre-endoscopy risk stratification in acute upper GI bleeding, suggesting outpatient management for GBS ≤ 1. Aspirin should not be interrupted for secondary cardiovascular prophylaxis and should be restarted within 3-5 days if stopped. Early (≤ 24 hours) upper GI endoscopy is recommended post-resuscitation, but urgent (<12 hours) endoscopy is not advised as it doesn't improve outcomes.
Esophageal motility disorders on high‐resolution manometry: Chicago classification version 4.0<sup>©</sup>
Neurogastroenterology & Motility · 2020 · Q1 · SJR 1.00 · FWCI 65.07 · 1,027 citations · Open access
The updated Chicago Classification v4.0 (CCv4.0) provides more rigorous and expansive criteria for diagnosing esophageal motility disorders using high-resolution manometry (HRM). It incorporates new testing positions, refined definitions for obstruction, and stricter diagnostic criteria to reduce ambiguity.
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