Proceedings of the National Academy of Sciences· 2018Q1
Gut microbiota regulates maturation of the adult enteric nervous system via enteric serotonin networks
- 568citations
- Q1SCImago
- 2018year
Short summary
Germ-free mice show an immature enteric nervous system (ENS) that matures upon colonization with a normal gut microbiota, driven by microbiota-induced serotonin release activating the 5-HT4 receptor.
AI-generated from the title and abstract; the full text is not read.
Key points
- Germ-free mice have an immature enteric nervous system (ENS).
- Colonization with a normal microbiota normalizes the ENS in adult mice.
- Microbiota-induced serotonin release activates the 5-HT4 receptor, mediating ENS maturation.
- This establishes a communication pathway between the gut microbiota and the ENS.
AI-generated from the title and abstract; the full text is not read.
Abstract
Significance The gut microbiota affects several physiological processes, including gut motility. Here we observed that germ-free mice have an immature enteric nervous system (ENS) that is normalized upon colonization with a normal microbiota. We identified the mechanism of communication between the microbiota and enteric neurons as the initiation of serotonin release and subsequent activation of the 5-HT 4 receptor. This demonstrates a strong interaction between the microbiota and the ENS and indicates potential mechanisms linking microbial dysbiosis to gastrointestinal disorders. The ability to modulate the microbiota, e.g., by diet, will open new perspectives of research in neurogastroenterology.
The authors' abstract, as published at the source. Proceedings of the National Academy of Sciences, 2018 · DOI ↗
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Field: Gastroenterology
GastroenterologyMedicine