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Proceedings of the National Academy of Sciences· 2018Q1

Gut microbiota regulates maturation of the adult enteric nervous system via enteric serotonin networks

Filipe De Vadder, E. Grasset, Louise Mannerås Holm, Gérard Karsenty et al.

Short summary

Germ-free mice show an immature enteric nervous system (ENS) that matures upon colonization with a normal gut microbiota, driven by microbiota-induced serotonin release activating the 5-HT4 receptor.

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Field: Gastroenterology

GastroenterologyMedicine