Animal Cells and Systems· 2026Q1
Matching developmental timelines of fish, frog, mouse and human brains
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- Q1SCImago
- 2026year
Short summary
Comparative developmental timelines reveal that while key vertebrate brain development events (neurogenesis, astrogliogenesis, GABA shift) are conserved, their relative durations vary significantly across species like fish, frogs, mice, and humans.
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Key points
- Key vertebrate brain development events like peak neurogenesis preceding astrogliogenesis, synaptic pruning, and GABA shift are conserved.
- The relative duration of these developmental events varies significantly across species, including fish, frogs, mice, and humans.
- Milestones such as live birth in mammals are not present in fish or frogs, necessitating careful consideration for translational research.
- Comparative timelines are presented as a resource for translational neuroscience, considering factors like microglial colonization and blood-brain barrier formation.
AI-generated from the title and abstract; the full text is not read.
Abstract
The overall structure and development of the central nervous system (CNS) are highly conserved among vertebrates. Peak neurogenesis generally precedes the main wave of astrogliogenesis; exuberant synapses are formed and pruned during critical periods; and the neurotransmitter gamma-aminobutyric acid (GABA) shifts from depolarizing to hyperpolarizing as the brain matures. The sequence of these key developmental events is broadly similar across vertebrate model organisms, including mouse, Xenopus, and zebrafish. Despite this overall similarity, the relative duration of each event varies substantially, and key events such as live birth in mammals do not occur in fish or frogs. These differences must be considered when translating findings from one species to another. In this review, we compare several developmental events that are relevant to modeling human diseases in animal models, including microglial colonization and blood–brain barrier formation. We also present comparative developmental timelines as a resource for translational neuroscience research.
The authors' abstract, as published at the source. Animal Cells and Systems, 2026 · DOI ↗
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Field: Developmental Neuroscience
Developmental NeuroscienceNeuroscience