Key papers in Developmental Neuroscience
Pofolia’s corpus holds 41 papers from the Developmental Neuroscience subfield (2012–2022). The list below starts with the most cited.
Most cited
Ranked by citation count. Because citations accumulate over time, this list naturally leans towards work published a few years ago; for where the field is now, see “recently added”.
Epigenetic Regulations of GABAergic Neurotransmission: Relevance for Neurological Disorders and Epigenetic Therapy
Medical Epigenetics · 2016 · FWCI 557.50 · 8,960 citations
This review highlights how epigenetic mechanisms like histone modifications, chromatin looping, and gene methylation regulate GABAergic neurotransmission, which is crucial for brain development and function.
Neuronal Activity Promotes Oligodendrogenesis and Adaptive Myelination in the Mammalian Brain
Science · 2014 · Q1 · SJR 10.00 · FWCI 42.94 · 1,455 citations
Neuronal activity directly stimulates the birth and maturation of myelin-producing cells (oligodendrocytes) and increases myelination in the brain. This activity-driven myelination improves motor function.
Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system
Science · 2016 · Q1 · SJR 10.00 · FWCI 48.38 · 1,202 citations
Single-cell RNA sequencing of over 5000 cells revealed 13 distinct oligodendrocyte populations in the mouse CNS, challenging the view of them as a homogeneous cell type.
Neurogenesis in the Adult Hippocampus
Cold Spring Harbor Perspectives in Biology · 2015 · Q1 · SJR 3.00 · 1,053 citations · Open access
Adult hippocampal neurogenesis generates new excitatory granule cells in the dentate gyrus, a process crucial for higher cognitive functions like memory and affective behaviors.
Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors
Science · 2014 · Q1 · SJR 10.00 · FWCI 42.67 · 1,051 citations · Open access
Young blood factors can rejuvenate the aging mouse brain by promoting vascular remodeling, increasing neurogenesis, and improving cognitive function.
Myelination of the Nervous System: Mechanisms and Functions
Annual Review of Cell and Developmental Biology · 2014 · Q1 · SJR 7.00 · FWCI 24.91 · 1,009 citations · Open access
Recent advances reveal the intricate mechanisms of myelin biogenesis, lifelong plasticity, and the crucial symbiotic relationship between myelinating glial cells and axons.
Glia as architects of central nervous system formation and function
Science · 2018 · Q1 · SJR 10.00 · FWCI 27.79 · 1,000 citations
Glia, once thought to be passive, actively orchestrate nearly all aspects of central nervous system (CNS) formation and function. Diverse glial cell types influence everything from neuron birth and migration to circuit assembly and synaptic communication.
Association Between a Single General Anesthesia Exposure Before Age 36 Months and Neurocognitive Outcomes in Later Childhood
JAMA · 2016 · Q1 · SJR 5.00 · FWCI 70.87 · 951 citations
A single exposure to general anesthesia before age 36 months in otherwise healthy children was not associated with significant differences in IQ or neurocognitive outcomes in later childhood compared to their unexposed siblings.
A Critical Period for Social Experience–Dependent Oligodendrocyte Maturation and Myelination
Science · 2012 · Q1 · SJR 10.00 · FWCI 21.51 · 941 citations
Social isolation during a specific post-weaning window in mice impairs prefrontal cortex myelination and cognitive function, with deficits persisting even after social reintroduction.
Oligodendrocytes: Myelination and Axonal Support
Cold Spring Harbor Perspectives in Biology · 2015 · Q1 · SJR 3.00 · 877 citations · Open access
Oligodendrocytes, the cells forming myelin in the central nervous system, are not just passive insulators but are metabolically active and actively support axonal integrity.
Modeling Transformations of Neurodevelopmental Sequences across Mammalian Species
Journal of Neuroscience · 2013 · Q1 · SJR 1.00 · FWCI 27.74 · 867 citations · Open access
A single model accurately predicts neurodevelopmental timing across 18 mammalian species, revealing that species' developmental rate correlates with adult brain size and identifying specific heterochronies like delayed corticogenesis in species with larger relative cortices.
Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer’s mouse model
Science · 2018 · Q1 · SJR 10.00 · FWCI 34.53 · 832 citations · Open access
Researchers successfully mimicked exercise's cognitive benefits in an Alzheimer's mouse model by combining the stimulation of new neuron growth (neurogenesis) with increased levels of brain-derived neurotrophic factor (BDNF). Neither intervention alone was sufficient.
Hippocampal Neurogenesis Regulates Forgetting During Adulthood and Infancy
Science · 2014 · Q1 · SJR 10.00 · FWCI 31.93 · 763 citations
New neurons in the hippocampus actively cause forgetting of existing memories in adult mice, a process that can be reversed by reducing neurogenesis.
Neurodevelopmental outcome at 5 years of age after general anaesthesia or awake-regional anaesthesia in infancy (GAS): an international, multicentre, randomised, controlled equivalence trial
The Lancet · 2019 · FWCI 45.78 · 734 citations
Infants undergoing short general anesthesia (under 1 hour) in early infancy showed no difference in full-scale IQ at age 5 compared to those receiving awake-regional anesthesia.
Prolonged myelination in human neocortical evolution
Proceedings of the National Academy of Sciences · 2012 · Q1 · SJR 3.00 · FWCI 13.66 · 734 citations · Open access
Human neocortical myelination extends significantly longer into development compared to chimpanzees, with maturation continuing beyond late adolescence.
Myelin in the Central Nervous System: Structure, Function, and Pathology
Physiological Reviews · 2019 · Q1 · SJR 11.00 · FWCI 24.49 · 712 citations · Open access
Myelin, previously thought to solely enable fast nerve conduction, is now understood to have expanded roles including metabolic support to neurons and regulation of ion homeostasis.
The glia/neuron ratio: How it varies uniformly across brain structures and species and what that means for brain physiology and evolution
Glia · 2014 · Q1 · SJR 2.00 · FWCI 14.60 · 708 citations
Contrary to popular belief, the glia/neuron ratio does not increase with brain size, nor do glia comprise 90% of human brain cells. Instead, this ratio uniformly varies with decreasing neuronal density, driven by increasing average neuronal cell size.
Self-Organization of Polarized Cerebellar Tissue in 3D Culture of Human Pluripotent Stem Cells
Cell Reports · 2015 · Q1 · SJR 3.00 · FWCI 19.12 · 698 citations · Open access
Human pluripotent stem cells spontaneously self-organize in 3D culture to form a polarized cerebellar structure, generating functional Purkinje cells and mimicking early embryonic cerebellar development.
Ketamine Pharmacology: An Update (<i>Pharmacodynamics and Molecular Aspects, Recent Findings</i>)
CNS Neuroscience & Therapeutics · 2013 · Q1 · SJR 1.00 · FWCI 14.19 · 690 citations · Open access
Ketamine, a long-used anesthetic and analgesic, exerts its primary effects through NMDA receptor antagonism, which is crucial for its dissociative anesthesia, antidepressant, and analgesic properties.
Neural progenitors, neurogenesis and the evolution of the neocortex
Development · 2014 · Q1 · SJR 1.00 · FWCI 24.48 · 649 citations · Open access
The evolutionary expansion of the neocortex, particularly in humans, is linked to interspecies differences in the biology of neural progenitor cells and their neurogenic divisions.
Recently added
Hippocampus and its involvement in Alzheimer’s disease: a review
3 Biotech · 2022 · Q1 · FWCI 56.07 · 558 citations · Open access
The hippocampus, crucial for learning and memory, is significantly affected early in Alzheimer's disease (AD), showing rapid tissue loss and functional disconnection.
Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain
Science · 2020 · Q1 · SJR 10.00 · FWCI 33.13 · 503 citations
Plasma from exercised aged mice, enriched with the liver-derived enzyme Gpld1, transferred exercise's benefits for neurogenesis and cognition to sedentary aged mice.
Oligodendrocytes in Development, Myelin Generation and Beyond
Cells · 2019 · Q1 · SJR 1.00 · FWCI 19.59 · 605 citations · Open access
Oligodendrocytes, the myelinating cells of the CNS, are generated from adult progenitor cells and are crucial for axonal health, with their pathology linked to diseases like multiple sclerosis and Alzheimer's. Recent findings reveal novel immunomodulatory roles for these cells, though their implications remain unclear.
Long-term neurocognitive benefits of FLASH radiotherapy driven by reduced reactive oxygen species
Proceedings of the National Academy of Sciences · 2019 · Q1 · SJR 3.00 · FWCI 27.07 · 592 citations
FLASH radiotherapy preserves long-term neurocognitive function in mice by significantly reducing reactive oxygen species (ROS) compared to conventional (CONV) irradiation.
Myelin in the Central Nervous System: Structure, Function, and Pathology
Physiological Reviews · 2019 · Q1 · SJR 11.00 · FWCI 24.49 · 712 citations · Open access
Myelin, previously thought to solely enable fast nerve conduction, is now understood to have expanded roles including metabolic support to neurons and regulation of ion homeostasis.
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